Journal ArticleDOI
Sending the right signal: Notch and stem cells.
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TLDR
The current state of knowledge of how the Notch receptor is controlled through its interaction with ligands and how this is regulated by associated factors is described and the functional consequences of Notch receptors activation on cell fate decisions are discussed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-02-01. It has received 84 citations till now. The article focuses on the topics: Notch signaling pathway & Notch proteins.read more
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Notch signaling at a glance
TL;DR: The molecular biology of Notch signaling, its role in development and its relevance to disease are summarized.
Journal ArticleDOI
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Mark A. Feitelson,Alla Arzumanyan,Rob J. Kulathinal,Stacy W. Blain,Randall F. Holcombe,Jamal Mahajna,Maria Marino,María L. Martínez-Chantar,Roman Nawroth,Isidro Sánchez-García,Dipali Sharma,Neeraj K. Saxena,Neetu Singh,Panagiotis J. Vlachostergios,Shanchun Guo,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Alan Bilsland,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Sulma I. Mohammed,Asfar S. Azmi,Dipita Bhakta,Dorota Halicka,W. Nicol Keith,Somaira Nowsheen +33 more
TL;DR: Natural compounds found to inhibit one or more pathways that contribute to proliferation have been found and will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.
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Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology
TL;DR: The results validate the notion that important insights on complex host-microbe relationships can be obtained from the use of a well-established and genetically tractable invertebrate model and identify temporally responsive genes and showed that the overall impact of microbiota was greater in older flies.
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Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1)
TL;DR: It is demonstrated that MSC spontaneously aggregated into sphere‐like structures after injection into a subcutaneous air pouch or the peritoneum of mice, indicating that assembly of MSC into spheres triggers caspase‐dependent IL1 signaling and the secretion of modulators of inflammation and immunity.
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Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.
Amanda J. Collier,Amanda J. Collier,Sarita Panula,Sarita Panula,John P. Schell,John P. Schell,Peter Chovanec,Alvaro Plaza Reyes,Alvaro Plaza Reyes,Sophie Petropoulos,Sophie Petropoulos,Anne E. Corcoran,Rachael C. Walker,Iyadh Douagi,Fredrik Lanner,Fredrik Lanner,Peter J. Rugg-Gunn,Peter J. Rugg-Gunn +17 more
TL;DR: Complete profiling of cell surface proteins by flow cytometry in naive and primed human PSCs revealed distinct transcriptional and X chromosome inactivation changes associated with the early and late stages of naive cell formation.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.