Setting research priorities to improve global newborn health and prevent stillbirths by 2025.
Sachiyo Yoshida,Jose Martines,Joy E Lawn,Joy E Lawn,Stephen Wall,João Paulo Souza,Igor Rudan,Simon Cousens,Peter Aaby,Ishag Adam,Ramesh K. Adhikari,Namasivayam Ambalavanan,Shams Ei Arifeen,Dhana Raj Aryal,S. K. Asiruddin,Abdullah H Baqui,Aluísio J D Barros,Christine Stabell Benn,Vineet Bhandari,Shinjini Bhatnagar,Sohinee Bhattacharya,Zulfiqar A Bhutta,Robert E. Black,Hannah Blencowe,Carl L. Bose,Justin Brown,Christoph Bührer,Wally Carlo,José Guilherme Cecatti,Po Yin Cheung,Robert Clark,Tim Colbourn,Agustin Conde-Agudelo,Erica Corbett,Andrew E. Czeizel,Abhik Das,Louise T Day,Carolyn Deal,Ashok K. Deorari,Ugur Dilmen,Mike English,Mike English,Cyril Engmann,Fabian Esamai,Caroline H.D. Fall,Donna M. Ferriero,Peter Gisore,Tabish Hazir,Rosemary D. Higgins,Caroline S.E. Homer,Dewan Md Emdadul Hoque,Lorentz M. Irgens,M. T. Islam,Joseph de Graft-Johnson,Martias Alice Joshua,William J. Keenan,Soofia Khatoon,Helle Kieler,Michael S. Kramer,Eve M. Lackritz,Tina Lavender,Laurensia Lawintono,Richard Luhanga,David R. Marsh,Douglas McMillan,Patrick J. McNamara,Ben W.J. Mol,Elizabeth Molyneux,Gelasius Mukasa,Miriam Mutabazi,Luis Nacul,Margaret Nakakeeto,Indira Narayanan,Bolajoko O. Olusanya,David Osrin,Vinod K. Paul,Christian F. Poets,Uma M. Reddy,Mathuram Santosham,Rubayet Sayed,Natalia Schlabritz-Loutsevitch,Nalini Singhal,Mary Alice Smith,Pete Smith,Sajid Bashir Soofi,Catherine Y. Spong,Shahin Sultana,Antoinette Tshefu,Frank van Bel,Lauren Vestewig Gray,Peter Waiswa,Wei Wang,Sarah Williams,Linda L. Wright,Anita K. M. Zaidi,Yanfeng Zhang,Nanbert Zhong,Isabel Zuniga,Rajiv Bahl +98 more
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TLDR
Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list.Abstract:
BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.read more
Citations
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Journal ArticleDOI
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
Ge Zhang,Bjarke Feenstra,Jonas Bacelis,Xueping Liu,Lisa M. Muglia,Julius Juodakis,Daniel Miller,Nadia K. Litterman,Pan Pan Jiang,Laura Russell,David A. Hinds,Youna Hu,Matthew T. Weirauch,Xiaoting Chen,Arun R. Chavan,Günter P. Wagner,Günter P. Wagner,Mihaela Pavlicev,Mauris C. Nnamani,Jamie Maziarz,Minna K. Karjalainen,Minna K. Karjalainen,Mika Rämet,Mika Rämet,Verena Sengpiel,Frank Geller,Heather A. Boyd,Aarno Palotie,Aarno Palotie,Aarno Palotie,Allison Momany,Bruce Bedell,Kelli K Ryckman,Johanna M. Huusko,Johanna M. Huusko,Johanna M. Huusko,Carmy Forney,Leah C. Kottyan,Mikko Hallman,Mikko Hallman,Mikko Hallman,Kari Teramo,Ellen A. Nohr,George Davey Smith,Mads Melbye,Mads Melbye,Mads Melbye,Bo Jacobsson,Louis J. Muglia +48 more
TL;DR: It is found that variants at the EBF1, EEFSEC, AGTR2, WNT4, ADCY5, and RAP2C loci were associated with gestational duration and variants atThe EBF 1, EE FSEC, and AG TR2 loci with preterm birth.
Journal ArticleDOI
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
Ge Zhang,Bjarke Feenstra,Jonas Bacelis,Xueping Liu,Lisa M. Muglia,Julius Juodakis,Daniel Miller,Nadia K. Litterman,Pan Pan Jiang,Laura Russell,David A. Hinds,Youna Hu,Matthew T. Weirauch,Xiaoting Chen,Arun R. Chavan,Günter P. Wagner,Günter P. Wagner,Mihaela Pavlicev,Mihaela Pavlicev,Mauris C. Nnamani,Jamie Maziarz,Minna K. Karjalainen,Minna K. Karjalainen,Mika Rämet,Mika Rämet,Verena Sengpiel,Frank Geller,Heather A. Boyd,Aarno Palotie,Aarno Palotie,Aarno Palotie,Allison Momany,Bruce Bedell,Kelli K Ryckman,Johanna M. Huusko,Johanna M. Huusko,Johanna M. Huusko,Carmy Forney,Leah C. Kottyan,Mikko Hallman,Mikko Hallman,Kari Teramo,Ellen A. Nohr,George Davey Smith,Mads Melbye,Mads Melbye,Bo Jacobsson,Bo Jacobsson,Louis J. Muglia +48 more
TL;DR: A genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome is performed.
Journal ArticleDOI
Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews
TL;DR: In this article, the authors presented a summary of all evidence for interventions relevant to the prevention of preterm birth as reported in Cochrane systematic reviews (SRs), aiming to highlight promising interventions and to identify SRs in need of an update.
Journal ArticleDOI
Clinical guidelines for prevention and management of preterm birth: a systematic review
TL;DR: Clinical practice guidelines (CPG) endorse multiple strategies to prevent or manage preterm birth (PTB); however, not all strategies are proven to be effective.
Journal ArticleDOI
Labour management guidelines for a Tanzanian referral hospital: The participatory development process and birth attendants' perceptions.
Nanna Maaløe,Natasha Housseine,Jos van Roosmalen,Ib C. Bygbjerg,Britt Pinkowski Tersbøl,Rashid Saleh Khamis,Birgitte Bruun Nielsen,Tarek Meguid +7 more
TL;DR: The PartoMa guidelines ensure readily available, locally achievable, and acceptable support for intrapartum surveillance, triage, and management at a Tanzanian referral hospital.
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