Journal ArticleDOI
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.
TLDR
Recently, growing evidence supports significant involvement of immune dysfunction in the etiology of neurodegenerative diseases, several of which also display prominent sex differences across prevalence, pathology, and symptomology as discussed by the authors.About:
This article is published in Biological Psychiatry.The article was published on 2022-01-01. It has received 22 citations till now. The article focuses on the topics: Neurodegeneration & Disease.read more
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Journal ArticleDOI
Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age
TL;DR: The neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities is highlighted.
Journal ArticleDOI
Distinct grey matter volume alterations in adult patients with panic disorder and social anxiety disorder: A systematic review and voxel-based morphometry meta-analysis
TL;DR: PD and SAD may represent different anxiety sub-entities at the neuroanatomical phenotypes level, with different specific neurostructural deficits in the right IFG of PD patients, and the left striatum and thalamus of SAD patients.
Journal ArticleDOI
Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease
Steven N. Austad,Asim Najmi,Scott W. Ballinger,Thomas W. Buford,Christy S. Carter,Daniel L. Smith,Victor M. Darley-Usmar,Jianhua Zhang +7 more
TL;DR: As a major part of intracellular metabolism, mitochondrial bioenergetics, mitochondrial quality-control mechanisms, and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions.
Journal ArticleDOI
Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease
Jaclyn Eissman,Logan Dumitrescu,Emily R. Mahoney,Alexandra N. Smith,Shubhabrata Mukherjee,Michael L. Lee,Phoebe Scollard,Seo-Eun Choi,William S. Bush,Corinne D. Engelman,Qiongshi Lu,David W. Fardo,Emily H. Trittschuh,Jesse Mez,Catherine C. Kaczorowski,Hector Hernandez Saucedo,Keith F. Widaman,Rachel F. Buckley,Michael J. Properzi,Elizabeth C. Mormino,Hyun-Sik Yang,Theresa M. Harrison,Trey Hedden,Kwangsik Nho,Shea J. Andrews,Douglas Tommet,Niran Hadad,R. Elizabeth Sanders,Douglas M. Ruderfer,Katherine A. Gifford,Xiaoyuan Zhong,Neha S. Raghavan,Badri N. Vardarajan,Margaret A. Pericak-Vance,Lindsay A. Farrer,Li-San Wang,Carlos Cruchaga,Gerard D. Schellenberg,Nancy J. Cox,Jonathan L. Haines,C. Dirk Keene,Andrew J. Saykin,Eric B. Larson,Reisa A. Sperling,Richard Mayeux,Michael L. Cuccaro,David A. Bennett,Julie A. Schneider,Paul K. Crane,Angela L. Jefferson,Timothy J. Hohman +50 more
TL;DR: The findings support the theory that the most successful treatment for an individual with Alzheimer’s disease may be personalized based on their biological sex and genetic context, and identify sex differences in the genetic architecture of resilience.
Journal ArticleDOI
17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway.
TL;DR: In this article, a single subcutaneous injection of glutamate (10 mg/kg) induced brain oxidative stress after 4 h by disturbing the homeostasis of glutathione (GSH) and revealed an upsurge in ROS and LPO levels and downregulated the expression of Nrf2 and HO-1 antioxidant protein.
References
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2016 Alzheimer's disease facts and figures
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Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Lindsay A. Farrer,L. Adrienne Cupples,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Richard H. Myers,Margaret A. Pericak-Vance,Neil Risch,Cornelia M. van Duijn +9 more
TL;DR: The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
Journal ArticleDOI
Sex differences in immune responses
Sabra L. Klein,Katie L. Flanagan +1 more
TL;DR: It is emphasized that sex is a biological variable that should be considered in immunological studies and contribute to variations in the incidence of autoimmune diseases and malignancies, susceptibility to infectious diseases and responses to vaccines in males and females.
Journal ArticleDOI
Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination.
Claudia F. Lucchinetti,Wolfgang Brück,Joseph E. Parisi,Bernd W. Scheithauer,Moses Rodriguez,Hans Lassmann +5 more
TL;DR: At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Journal ArticleDOI
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Hadas Keren-Shaul,Amit Spinrad,Assaf Weiner,Assaf Weiner,Orit Matcovitch-Natan,Raz Dvir-Szternfeld,Tyler K. Ulland,Eyal David,Kuti Baruch,David Lara-Astaiso,Beáta Tóth,Shalev Itzkovitz,Marco Colonna,Michal Schwartz,Ido Amit +14 more
TL;DR: A novel microglia type associated with neurodegenerative diseases (DAM) is described and it is revealed that the DAM program is activated in a two-step process that involves downregulation of microglian checkpoints, followed by activation of a Trem2-dependent program.