Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
Satu Vainikka,Vladimir Joukov,S Wennström,Mathias Bergman,Pier Giuseppe Pelicci,Kari Alitalo +5 more
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FGFR-4 induced only a barely detectable phosphorylation of the cellular serine/threonine kinase Raf-1 and a weaker tyrosyl phosphorylated of mitogen-activated protein kinases than FGFR-1, and stimulation of both receptors resulted in increased DNA synthesis.About:
This article is published in Journal of Biological Chemistry.The article was published on 1994-07-15 and is currently open access. It has received 140 citations till now. The article focuses on the topics: Tyrosine phosphorylation & Phosphorylation.read more
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Fibroblast growth factor signalling: from development to cancer
Nicholas C. Turner,Richard Grose +1 more
TL;DR: There is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed.
Journal ArticleDOI
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Itaru Urakawa,Yuji Yamazaki,Takashi Shimada,Kousuke Iijima,Hisashi Hasegawa,Katsuya Okawa,Toshiro Fujita,Seiji Fukumoto,Takeyoshi Yamashita +8 more
TL;DR: It is shown that a previously undescribed receptor conversion by Klotho, a senescence-related molecule, generates the FGF23 receptor, and insights into the diversity and specificity of interactions between FGF and FGF receptors are provided.
Journal ArticleDOI
Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy
Alexander Grabner,Ansel P. Amaral,Karla Schramm,Saurav Singh,Alexis Sloan,Christopher Yanucil,Jihe Li,Lina A. Shehadeh,Joshua M. Hare,Valentin David,Valentin David,Aline Martin,Aline Martin,Alessia Fornoni,Giovana Seno Di Marco,Dominik Kentrup,Stefan Reuter,Anna B. Mayer,Hermann Pavenstädt,Jörg Stypmann,Christian Kuhn,Susanne Hille,Norbert Frey,Maren Leifheit-Nestler,Beatrice Richter,Dieter Haffner,Reimar Abraham,Johannes Bange,Bianca Sperl,Axel Ullrich,Marcus Brand,Myles Wolf,Christian Faul +32 more
TL;DR: It is reported that FGF23 exclusively activates FGFR4 on cardiac myocytes to stimulate phospholipase Cγ/calcineurin/nuclear factor of activated T cell signaling and promotes LVH by activatingFGFR4, thereby establishing FGFR 4 as a pharmacological target for reducing cardiovascular risk in CKD.
Journal ArticleDOI
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
TL;DR: It is demonstrated that autophosphorylation on tyrosines 653 and 654 is important for activation of tyrosine kinase activity of FGFR1 and is therefore essential forFGFR1-mediated biological responses.
Journal ArticleDOI
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Enrica Migliaccio,Simonetta Mele,Anna Elisabetta Salcini,Giuliana Pelicci,Ka‐Man Venus Lai,Giulio Superti-Furga,Tony Pawson,Pier Paolo Di Fiore,Pier Paolo Di Fiore,Luisa Lanfrancone,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +11 more
TL;DR: Three Shc proteins, p52shc/p46shc and p66shc, appear to exert different effects on the EGFR‐MAP kinase and other signalling pathways that control fos promoter activity, and Regulation of p66 shc expression might influence the cellular response to growth factors.
References
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Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.
Journal ArticleDOI
The heparin-binding (fibroblast) growth factor family of proteins.
Wilson H. Burgess,Thomas Maciag +1 more
Journal ArticleDOI
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
E. Lowenstein,Roger J. Daly,A. Batzer,W. Li,B. Margolis,Richard L. Lammers,Axel Ullrich,Edward Y. Skolnik,Dafna Bar-Sagi,Joseph Schlessinger +9 more
TL;DR: Results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling.
Journal ArticleDOI
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Giuliana Pelicci,Luisa Lanfrancone,Francesco Grignani,J McGlade,Federica Cavallo,Guido Forni,Ildo Nicoletti,Fausto Grignani,Tony Pawson,Pier Giuseppe Pelicci +9 more
TL;DR: The results suggest that the SHC gene products couple activated growth factor receptors to a signaling pathway that regulates the proliferation of mammalian cells.
Journal ArticleDOI
Protein kinase C alpha activates RAF-1 by direct phosphorylation
Walter Kolch,Gisela Heidecker,Georg Kochs,Richard Hummel,Haleh Vahidi,Harald Mischak,Günter Finkenzeller,Dieter Marmé,Ulf R. Rapp +8 more
TL;DR: The observation that Raf-1 and PKCα cooperate in the transformation of NIH3T3 cells is consistent with such a direct interaction, and the Ser499 phosphorylation site is necessary for this synergism.
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