Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase
TLDR
Btk is established as a key signaling molecule that interacts with and acts downstream of TLR8 and TLR9, and peripheral blood mononuclear cells from patients with X-linked agammaglobulinaemia that have dysfunctional Btk are impaired in the induction of interleukin-6 by CpGB-DNA.About:
This article is published in Journal of Biological Chemistry.The article was published on 2007-12-21 and is currently open access. It has received 111 citations till now. The article focuses on the topics: Bruton's tyrosine kinase & Tyrosine kinase.read more
Citations
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Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
Nan Wang,Hongwei Liang,Ke Zen +2 more
TL;DR: Identification of the molecules associated with the dynamic changes of macrophage polarization and understanding their interactions is crucial for elucidating the molecular basis of disease progression and designing novel macrophages-mediated therapeutic strategies.
Journal ArticleDOI
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
Abdalla J. Mohamed,Liang Yu,Carl-Magnus Bäckesjö,Leonardo Vargas,Rani Faryal,Rani Faryal,Alar Aints,Alar Aints,Birger Christensson,Anna Berglöf,Mauno Vihinen,Beston F. Nore,C. I. Edvard Smith +12 more
TL;DR: Novel mutations in the pleckstrin homology domain investigated for their transforming capacity are described and it is shown that the mutant D43R behaves similar to E41K, already known to possess such activity.
Journal ArticleDOI
Role of Bruton's tyrosine kinase in B cells and malignancies
TL;DR: Efficacy of BTK inhibition as a single agent therapy is strong, but resistance may develop, fueling the development of combination therapies that improve clinical responses and highlighting the importance ofBTK inhibition in cancer therapy.
Journal ArticleDOI
Primary B Cell Immunodeficiencies: Comparisons and Contrasts
Mary Ellen Conley,A. Kerry Dobbs,Dana Farmer,Sebnem Kilic,Kenneth Paris,Sofia Grigoriadou,Elaine Coustan-Smith,Vanessa Howard,Dario Campana +8 more
TL;DR: Identifying the genetic and environmental factors that influence the clinical phenotype may enhance patient care and the understanding of normal B cell development.
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When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction
TL;DR: These recent findings emphasize the importance of considering TLR signaling in the context of other signaling pathways, as is likely to occur in vivo during infection and inflammation.
References
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A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
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