Journal ArticleDOI
Statins and the risk of dementia.
Hershel Jick,Gwen L. Zornberg,Gwen L. Zornberg,Susan S. Jick,Sudha Seshadri,David A. Drachman +5 more
TLDR
Individuals of 50 years and older who were prescribed statins had a substantially lowered risk of developing dementia, independent of the presence or absence of untreated hyperlipidaemia, or exposure to nonstatin LLAs.About:
This article is published in The Lancet.The article was published on 2000-11-11. It has received 1637 citations till now. The article focuses on the topics: Dementia & Vascular dementia.read more
Citations
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Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Mild cognitive impairment
Serge Gauthier,Barry Reisberg,Michael Zaudig,Ronald C. Petersen,Karen Ritchie,Karl Broich,Sylvie Belleville,Henry Brodaty,David A. Bennett,Howard Chertkow,Jeffrey L. Cummings,Mony J. de Leon,Howard Feldman,Mary Ganguli,Harald Hampel,Philip Scheltens,Mary C. Tierney,Peter J. Whitehouse,Bengt Winblad +18 more
TL;DR: Mild cognitive impairment can be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension.
Journal ArticleDOI
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
James Shepherd,Gerard J. Blauw,Michael B. Murphy,Edward L.E.M. Bollen,Brendan M. Buckley,Stuart M. Cobbe,Ian Ford,Allan Gaw,Michael E. Hyland,J. Wouter Jukema,Adriaan M. Kamper,Peter W. Macfarlane,A. Edo Meinders,John Norrie,Chris J. Packard,Ivan J. Perry,David J. Stott,Brian Sweeney,Gillian Twomey,Rudi G. J. Westendorp +19 more
TL;DR: Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals and was extended to elderly individuals the treatment strategy currently used in middle aged people.
Journal ArticleDOI
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
Sally A. Shumaker,Claudine Legault,Stephen R. Rapp,Leon J. Thal,Robert B. Wallace,Judith K. Ockene,Susan L. Hendrix,Beverly N. Jones,Annlouise R. Assaf,Rebecca D. Jackson,Jane Morley Kotchen,Sylvia Wassertheil-Smoller,Jean Wactawski-Wende +12 more
TL;DR: Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Book
Evidence-Based Medicine: How to Practice and Teach EBM
TL;DR: This chapter discusses how to ask clinical questions you can answer and critically assess the evidence for evidence-based medicine, as well as 7 Rapid Reference Cards used in clinical practice.
Journal ArticleDOI
Vascular dementia Diagnostic criteria for research studies: Report of the NINDS‐AIREN International Workshop*
Gustavo C. Román,Thomas K. Tatemichi,T. Erkinjuntti,Jeffrey L. Cummings,Joseph C. Masdeu,J. H. Garcia,L. Amaducci,J. M. Orgogozo,A. Brun,Albert Hofman,D. M. Moody,M. D. O’Brien,T. Yamaguchi,Jordan Grafman,B. P. Drayer,D. A. Bennett,Marc Fisher,J. Ogata,E. Kokmen,F. Bermejo,Philip A. Wolf,P. B. Gorelick,K. L. Bick,A. K. Pajeau,M. A. Bell,Charles DeCarli,A. Culebras,Amos D. Korczyn,J. Bogousslavsky,A. Hartmann,P. Scheinberg +30 more
TL;DR: These criteria for the diagnosis of vascular dementia are intended as a guide for case definition in neuroepidemiologic studies, stratified by levels of certainty (definite, probable, and possible).
Journal ArticleDOI
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) Report of the consortium on DLB international workshop
Ian G. McKeith,Douglas Galasko,Kenji Kosaka,Elaine K. Perry,Dennis W. Dickson,L. A. Hansen,David P. Salmon,James Lowe,Suzanne S. Mirra,E. J. Byrne,Graham Lennox,Niall Quinn,J.A. Edwardson,Paul G. Ince,Catherine Bergeron,Alistair Burns,Bruce L. Miller,Simon Lovestone,Daniel Collerton,E. N. H. Jansen,Clive Ballard,R. A. I. De Vos,Gordon K. Wilcock,Kurt A. Jellinger,Robert H. Perry +24 more
TL;DR: This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
Journal ArticleDOI
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. St. George-Hyslop,Margaret A. Pericak-Vance,S. H. Joo,B.L. Rosi,James F. Gusella,D. R. Crapper-MacLachlan,Mark J. Alberts,Christine M. Hulette,Barbara J. Crain,Dmitry Goldgaber,A. D. Roses +13 more
TL;DR: Data support the involvement of ApoE ϵ4 in the pathogenesis of late-onset familial and sporadic AD and suggest it may operate as a susceptibility gene (risk factor) for the clinical expression of AD.
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Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
James Shepherd,Gerard J. Blauw,Michael B. Murphy,Edward L.E.M. Bollen,Brendan M. Buckley,Stuart M. Cobbe,Ian Ford,Allan Gaw,Michael E. Hyland,J. Wouter Jukema,Adriaan M. Kamper,Peter W. Macfarlane,A. Edo Meinders,John Norrie,Chris J. Packard,Ivan J. Perry,David J. Stott,Brian Sweeney,Gillian Twomey,Rudi G. J. Westendorp +19 more