Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
Citations
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Journal ArticleDOI
The Intricate Epigenetic and Transcriptional Alterations in Pediatric High-Grade Gliomas: Targeting the Crosstalk as the Oncogenic Achilles’ Heel
TL;DR: Molecular specificities of pHGGs subcategories are reviewed in the context of epigenomic rewiring caused by H3 mutations and the subsequent oncogenic interplay with transcriptional signaling pathways co-opted from developmental programs that ultimately leads to gliomagenesis.
Journal ArticleDOI
Human cortical interneuron development unraveled
TL;DR: Paredes et al. as discussed by the authors found a distinctive cellular organization of the embryonic brain area where cortical interneurons are born and an extended period of neurogenesis in humans compared with rodents, explaining how interneuron numbers have increased.
Journal ArticleDOI
Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns
Linnea R. Vose,Govindaiah Vinukonda,Daniel Diamond,Ritesh Korumilli,Furong Hu,Muhammad T. Zia,Robert F. Hevner,Praveen Ballabh +7 more
TL;DR: It is found that prenatal GCs did not affect the densities of radial glia and intermediate progenitors of glutamatergic or GABAergic neurons, and treatment does not significantly impact the balance of glut AMG and GABAergic neurogenesis in premature infants.
Book ChapterDOI
Epigenetics in Child Psychiatry
Josephine Elia,Richard Kingsley,Oliver Yost,Charles Bongiorno,Carolyn Green Bernacki,Alexander Ambrosini,Makiko Okuyama,Hakon Hakonarson +7 more
TL;DR: The mechanisms by which epigenetic factors silence or enhance gene expression in child psychiatric disorders remains to be discovered, and recent advances in the role of microRNAs and epigenetic reconfiguration in normal brains will undoubtedly accelerate discoveries.
Posted ContentDOI
Altered patterning of interneuron progenitors in Down syndrome
Yathindar Giffin-Rao,Bennett Strand,Leslie Huang,Margaret Medo,Bradley Levesque,Roger A Daley,Lindsey Amundson,Aratrika Keshan,Rebecca Reese,Daifeng Wang,Su-Chun Zhang,Anita Bhattacharyya +11 more
TL;DR: It is suggested that abnormal patterning of human Ts21 interneuron progenitors alters the generation of interneurons in DS and contributes to the reduced neurogenesis in DS.
References
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Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
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