Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical development
TL;DR: A new dynamic genomic network model is proposed, for inferring patterns of genomic regulatory influence in dynamic processes such as development, and the method is computationally efficient, and can be applied to genome-wide data with tens of thousands of transcripts.
Journal ArticleDOI
Histone Methyltransferase SETDB1 Regulates the Development of Cortical Htr3a-Positive Interneurons and Mood Behaviors
Jiaqi Li,Shenghui Zheng,Yuhao Dong,Hao Xu,Yueyan Zhu,Jie Weng,Daijing Sun,Shun-Chung Wang,Lei Xiao,Yanping Jiang +9 more
TL;DR: In this paper , Setdb1-Gad2-cKO mice exhibited anxiety-and depressive-like behaviors, which were partially reversed by a 5-HT3 receptor antagonist.
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Neocortical Expansion and Neurodevelopmental Disease
TL;DR: The molecular and cellular characteristics of mammalian cerebral cortex expansion and the related disease are discussed.
Posted ContentDOI
Cellular resolution anatomical and molecular atlases for prenatal human brains
Songlin Ding,Joshua J. Royall,Phil Lesnar,Benjamin A.C. Facer,Kimberly A. Smith,Yina Wei,Kristina Brouner,Rachel A. Dalley,Nick Dee,Tim A. Dolbeare,Amanda Ebbert,Ian A. Glass,Katie Glattfelter,Nika H. Keller,Felix Lee,Tracy Lemon,Julie Nyhus,Julie Pendergraft,Robert Reid,Melaine Sarreal,Nadiya V. Shapovalova,Aaron Szafer,John W. Phillips,Susan M. Sunkin,John G. Hohmann,Allan R. Jones,Michael Hawrylycz,Patrick R. Hof,Lydia Ng,Amy Bernard,Ed S. Lein +30 more
TL;DR: In this article, the authors present two cellular-resolution digital anatomical atlases for prenatal human brain at post-conceptional weeks (PCW) 15 and 21, annotated on sequential Nissl-stained sections covering brain-wide structures on the basis of combined analysis of cytoarchitecture, acetylcholinesterase staining and an extensive marker gene expression dataset.
Journal ArticleDOI
Current progress in brain organoid technology
TL;DR: This article focuses on the technologies and applications of brain organoids in modeling human brain development, and discusses the progress and challenges of various pivotal technologies in brain organoid studies, including vascularization, gene editing, single-cell sequencing, and other engineering approaches.
References
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Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
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