Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
Reads0
Chats0
TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
Citations
More filters
Journal ArticleDOI
Brain Organoids—A Bottom-Up Approach for Studying Human Neurodevelopment
Eyal Karzbrun,Orly Reiner +1 more
TL;DR: How organoids are used to model neurodevelopmental diseases and challenges in organoid systems are described and how to approach these challenges using complementary bioengineering techniques are described.
Journal ArticleDOI
The COUP-TFII/neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain
Shigeaki Kanatani,Takao Honda,Michihiko Aramaki,Kanehiro Hayashi,Ken Ichiro Kubo,Mami Ishida,Daisuke H. Tanaka,Takeshi Kawauchi,Katsutoshi Sekine,Sayaka Kusuzawa,Takahiko Kawasaki,Tatsumi Hirata,Hidenori Tabata,Per Uhlén,Kazunori Nakajima +14 more
TL;DR: It is shown that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)–induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of POa-derived GABAergic neurons.
Journal ArticleDOI
Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABAAR subunits.
TL;DR: An analysis of GABA receptor subunit expression from single-cell and global transcriptome data generated by the Allen Institute finds that transcriptional expression of GABAAR subunits is anatomically organized according to their neurodevelopmental origin.
Journal ArticleDOI
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Chandrasekhar S. Raju,Julien Spatazza,Amelia Stanco,Phillip Larimer,Shawn F. Sorrells,Kevin W. Kelley,Cory R. Nicholas,Mercedes F. Paredes,Jan H. Lui,Jan H. Lui,Andrea R. Hasenstaub,Arnold R. Kriegstein,Arturo Alvarez-Buylla,John L.R. Rubenstein,Michael C. Oldham +14 more
TL;DR: It is shown here that the calcium-binding protein secretagogin (SCGN) is robustly expressed by neocortical GABAergic neurons derived from caudal ganglionic eminences and lateral ganglionics during human but not mouse brain development.
Journal ArticleDOI
Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function.
Daniel T. Gray,Carol A. Barnes +1 more
TL;DR: How nonhuman primate research has enriched the authors' understanding of cognitive and sensory decline in the aging brain, as well as how this work has been important for translating mechanistic implications derived from experiments conducted in rodents to human brain aging research are highlighted.
References
More filters
Journal ArticleDOI
Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
Journal ArticleDOI
Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.