Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
Citations
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Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrain.
Yifei Yang,Sam A. Booker,James M. Clegg,Idoia Quintana-Urzainqui,Anna Sumera,Zrinko Kozic,Owen Dando,Martin Lorenzo S,Yann Herault,Peter C. Kind,Price Dj,Thomas Pratt +11 more
TL;DR: This paper found no change in the numbers or position of either excitatory or inhibitory neurons in the somatosensory cortex or CA1 of 16p11.2+/- rats but found that CA1 Sst INs were hyperexcitable with an enlarged axon initial segment, which was not the case for CA1 pyramidal cells.
Posted ContentDOI
Neuroblast migration along cellular substrates in the developing porcine brain
TL;DR: In this paper, the authors evaluate the association between young interneuronal migratory streams and their preferred cellular substrates in gyrencephalic piglets during the developmental equivalent of human birth, infancy, and toddlerhood.
Journal ArticleDOI
microRNA-dependent regulation of gene expression in GABAergic interneurons
TL;DR: The role of miRNAs in inhibitory interneurons is discussed in this article , where the authors discuss recent progress in understanding miRNA-dependent regulation of gene expression in interneuron development and function, and how their dysregulation may underlie the emergence of neurodevelopmental and neuropsychiatric disorders.
Journal ArticleDOI
The Importance of Studying Human Brain
TL;DR: It is considered that, although animal experiments play a vital role in understanding fundamental molecular and cellular mechanisms behind brain function, understanding of higher brain functions has to be based on understanding uniqueness of human circuitries.
Journal ArticleDOI
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
Jason K. Karimy,Jessie Newville,Cameron Sadegh,Jill A. Morris,Edwin S. Monuki,David D. Limbrick,James P. McAllister II,Jenna E. Koschnitzky,Maria K. Lehtinen,Lauren L. Jantzie +9 more
TL;DR: The 2019 Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydroceus, was held on November 4 and 5, 2019 at Washington University in St. Louis as mentioned in this paper .
References
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Cortical inhibitory neurons and schizophrenia
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Spatio-temporal transcriptome of the human brain
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TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
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Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.