Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Developmental origins of brain disorders: roles for dopamine
Kelli M. Money,Gregg D. Stanwood +1 more
TL;DR: Developmental effects of dopamine receptor signaling disruption occur before synaptogenesis and demonstrate novel roles for dopaminergic signaling beyond neuromodulation at the synapse, which are implicated in the pathophysiology of neuropsychiatric disorders.
Journal ArticleDOI
Molecular and cellular reorganization of neural circuits in the human lineage
André M. M. Sousa,Ying Zhu,Mary Ann Raghanti,Robert R. Kitchen,Marco Onorati,Marco Onorati,Andrew T.N. Tebbenkamp,Bernardo Stutz,Kyle A. Meyer,Mingfeng Li,Yuka Imamura Kawasawa,Yuka Imamura Kawasawa,Fuchen Liu,Raquel Garcia Perez,Marta Melé,Tiago Carvalho,Mario Skarica,Forrest O. Gulden,Mihovil Pletikos,Akemi Shibata,Alexa R. Stephenson,Melissa K. Edler,John J. Ely,John D. Elsworth,Tamas L. Horvath,Patrick R. Hof,Thomas M. Hyde,Joel E. Kleinman,Daniel R. Weinberger,Mark Reimers,Richard P. Lifton,Richard P. Lifton,Richard P. Lifton,Shrikant Mane,James P. Noonan,Matthew W. State,Ed S. Lein,James A. Knowles,Tomas Marques-Bonet,Tomas Marques-Bonet,Chet C. Sherwood,Mark Gerstein,Nenad Sestan +42 more
TL;DR: Comparing transcriptome and histology of human and nonhuman primate brains reveals changes that make humans unique, and diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
Journal ArticleDOI
Interneurons from embryonic development to cell-based therapy.
Derek G. Southwell,Cory R. Nicholas,Allan I. Basbaum,Michael P. Stryker,Arnold R. Kriegstein,John L.R. Rubenstein,Arturo Alvarez-Buylla +6 more
TL;DR: Transplanted interneurons have been shown to migrate and survive in diverse neural structures, including the cerebral cortex and the spinal cord and are a potential cell-based therapy for conditions such as epilepsy, Parkinson's disease, schizophrenia, anxiety, and chronic pain.
Journal ArticleDOI
Cortical interneuron development: a tale of time and space.
TL;DR: New insights into cortical GABAergic interneuron subtype specification are examined, focussing on spatial, temporal and genetic mechanisms regulating cell fate decisions in the mouse medial ganglionic eminence.
Journal ArticleDOI
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo.
TL;DR: Efforts to recapitulate brain development in neural organoids are described and their applicability for disease modeling, evolutionary studies and neural network research is focused on.
References
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Journal ArticleDOI
Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
Journal ArticleDOI
Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.