Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Conserved rules in embryonic development of cortical interneurons.
TL;DR: This review will focus on early aspects of cortical interneurons (cIN) development from specification to migration and final positioning in the human cerebral cortex, to better understand the developmental mechanisms underlying cIN differentiation in human.
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Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex
TL;DR: Paired recording showed that a calretinin-/COUP-TFII-positive interneuron elicited inhibitory postsynaptic potentials in a reciprocally connected pyramidal cell.
Journal ArticleDOI
The development and evolution of inhibitory neurons in primate cerebrum
Matthew T. Schmitz,Kadellyn Sandoval,Christopher P Chen,Mohammed A. Mostajo-Radji,William W. Seeley,Tomasz J. Nowakowski,Chun Ye,Mercedes F. Paredes,Alex A. Pollen +8 more
TL;DR: In this paper , the authors reconstruct gene expression trajectories specifying inhibitory neurons (INs) generated throughout the neurogenic period in macaques and mice by analysing the transcriptomes of 250,181 cells.
Journal ArticleDOI
Decoding Cortical Glial Cell Development
Xiaosu Li,Guoping Liu,Lin Yang,Zhenmeiyu Li,Zhuangzhi Zhang,Zhejun Xu,Yuqun Cai,Heng Du,Zihao Su,Ziwu Wang,Yangyang Duan,Haotian Chen,Zicong Shang,Yan You,Qi Zhang,Miao He,Bin Chen,Zhengang Yang +17 more
TL;DR: In this article, a single-cell RNA-Seq with intersectional lineage analyses was used to reveal the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocyte and Olfactory bulb interneurons.
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Cortical neurogenesis from pluripotent stem cells: Complexity emerging from simplicity
TL;DR: PSC-derived neurons can integrate into the brain following in vivo transplantation and display patterns of morphology and connectivity specific of cortical neurons, and emerges as a robust model that provides new ways to link cortical development, evolution, and disease.
References
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Cortical inhibitory neurons and schizophrenia
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TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
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Neurogenic radial glia in the outer subventricular zone of human neocortex
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