Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation
Taegon Kim,Ruiqin Yao,Travis Monnell,Jun-Hyeong Cho,Anju Vasudevan,Alice Koh,Kumar T. Peeyush,Minho Moon,Debkanya Datta,Vadim Y. Bolshakov,Kwang-Soo Kim,Sangmi Chung +11 more
TL;DR: It is proposed that signaling modulation recapitulating normal developmental patterns efficiently generate human GABAergic interneurons, which represents a novel tool in regenerative medicine, developmental studies, disease modeling, bioassay, and drug screening.
Journal ArticleDOI
Substantial DNA methylation differences between two major neuronal subtypes in human brain.
Alexey Kozlenkov,Minghui Wang,Panos Roussos,Sergei Rudchenko,Mihaela Barbu,Marina Bibikova,Brandy Klotzle,Andrew J. Dwork,Bin Zhang,Yasmin L. Hurd,Eugene V. Koonin,Michael Wegner,Stella Dracheva +12 more
TL;DR: The findings suggest that functional differences between neuronal subtypes are linked to their epigenetic specification, and regions that are differentially methylated in GABA and GLU neurons were significantly enriched for schizophrenia risk loci.
Journal ArticleDOI
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
Natalia V. De Marco García,Rashi Priya,Sebnem N. Tuncdemir,Gord Fishell,Theofanis Karayannis +4 more
TL;DR: It is suggested that thalamic inputs are critical in determining the balance between local and long-range connectivity and are fundamental to the proper integration of Reelin-expressing interneurons into nascent cortical circuits.
Journal ArticleDOI
Thinking out of the dish: what to learn about cortical development using pluripotent stem cells
Jelle van den Ameele,Jelle van den Ameele,Luca Tiberi,Pierre Vanderhaeghen,Ira Espuny-Camacho,Ira Espuny-Camacho +5 more
TL;DR: Findings are reviewed with emphasis on the new perspectives that PSC can differentiate into a wide range of cortical neurons in vitro, which can integrate appropriately into the brain following in vivo transplantation.
Journal ArticleDOI
Decision making during interneuron migration in the developing cerebral cortex
Jiami Guo,E.S. Anton +1 more
TL;DR: The cellular and molecular underpinnings of the major decision-making steps involved in the process of oriental navigation of cortical interneurons in the developing brain are examined.
References
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
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Neurogenic radial glia in the outer subventricular zone of human neocortex
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