Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
TL;DR: In this paper , a cross-species analysis revealed robust transcriptomic and histologic signatures of neurogenesis in the adult mouse, pig, and macaque, but not humans.
Journal ArticleDOI
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells.
Daniel Franjic,Mario Skarica,Shaojie Ma,Jon I. Arellano,Andrew T.N. Tebbenkamp,Jinmyung Choi,Chuan Xu,Qian Li,Yury M. Morozov,David Andrijevic,Zvonimir Vrselja,Ana Spajic,Gabriel Santpere,Mingfeng Li,Shupei Zhang,Yang Liu,Joshua Spurrier,Le Zhang,Ivan Gudelj,Lucija Rapan,Hideyuki Takahashi,Anita Huttner,Rong Fan,Stephen M. Strittmatter,Andre M.M. Sousa,Pasko Rakic,Nenad Sestan +26 more
TL;DR: In this article, a cross-species analysis revealed robust transcriptomic and histologic signatures of neurogenesis in the adult mouse, pig, and macaque, but not humans.
Journal ArticleDOI
Human Models Are Needed for Studying Human Neurodevelopmental Disorders.
Xinyu Zhao,Anita Bhattacharyya +1 more
TL;DR: Human-specific features of neurodevelopment and the most common neurodevelopmental disorders are summarized, discrepancies between animal models and human diseases are presented, how human stem cell models can provide meaningful information is demonstrated, and the challenges that exist are discussed.
Journal ArticleDOI
Immature excitatory neurons develop during adolescence in the human amygdala
Shawn F. Sorrells,Mercedes F. Paredes,Dmitry Velmeshev,Vicente Herranz-Pérez,Vicente Herranz-Pérez,Kadellyn Sandoval,Simone Mayer,Edward F. Chang,Ricardo Insausti,Arnold R. Kriegstein,John L.R. Rubenstein,José Manuel García-Verdugo,Eric J. Huang,Arturo Alvarez-Buylla +13 more
TL;DR: Evidence is found that the maturation of immature excitatory neurons in the human amygdala may be accelerated during puberty, a possible substrate for persistent plasticity at the interface of the hippocampus and amygdala.
Journal ArticleDOI
Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons.
Hai-Qin Huo,Zhuang-Yin Qu,Fang Yuan,Lixiang Ma,Lin Yao,Min Xu,Yao Hu,Jing Ji,Anita Bhattacharyya,Su-Chun Zhang,Yan Liu +10 more
TL;DR: It is suggested that impaired migration of DS GABAergic neurons may contribute to the reduced number of interneurons in the cerebral cortex and hippocampus in DS patients.
References
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
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