Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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The Age of Brain Organoids: Tailoring Cell Identity and Functionality for Normal Brain Development and Disease Modeling.
TL;DR: In this paper, the authors discuss how the technology behind brain organoids brought advances in understanding neurodevelopmental, pathogen-induced, and neurodegenerative diseases in the human brain.
Book ChapterDOI
Sculpting Cerebral Cortex with Serotonin in Rodent and Primate
Tania Vitalis,Catherine Verney +1 more
TL;DR: Evidence is recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5- HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.
Journal ArticleDOI
Generation of cerebral cortical GABAergic interneurons from pluripotent stem cells.
TL;DR: Recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human CIns in vitro is discussed.
Journal ArticleDOI
Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells
TL;DR: In this article, the authors explore the consequences of myelination for action potential propagation, for patterns of neuronal connectivity and for the expression of behavioral plasticity in cortical information processing.
Journal ArticleDOI
PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.
TL;DR: These findings provide evidence of a dramatic shift in excitability in the dentate gyrus of Pafah1b1+/− mice that may contribute to epilepsy or cognitive impairments associated with lissencephaly, and tangential migration of young GABAergic interneurons into the developing hippocampus is slowed.
References
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Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
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Cortical inhibitory neurons and schizophrenia
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Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.