Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
Jiwen Li,Chunyang Wang,Zhuangzhi Zhang,Yan Wen,Lei An,Qifei Liang,Zhejun Xu,Song Wei,Weiwei Li,Teng Guo,Guoping Liu,Guangxu Tao,Yan You,Heng Du,Zhuoning Fu,Miao He,Bin Chen,Kenneth Campbell,Arturo Alvarez-Buylla,John L.R. Rubenstein,Zhengang Yang +20 more
TL;DR: It is shown that Sp8 and Sp9 coordinately regulate OB interneuron development, and newly born neuroblasts in the V-SVZ-RMS-OB system fail to express Prokr2 and Tshz1 expression, genes with known roles in promoting OB interneeuron differentiation and migration, and that are involved in human Kallmann syndrome.
Journal ArticleDOI
Radial glia in the ventral telencephalon
TL;DR: Current knowledge about subpallial neural stem cells and their progeny is reviewed, focusing on the period of neurogenesis and the role of clonal lineage in the organization and specification of mature neurons.
Journal ArticleDOI
Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
Luis Puelles,Nicanor Morales-Delgado,Paloma Merchán,Paloma Merchán,B. Castro-Robles,M. Martínez-de-la-Torre,Carmen Diaz,José Luis Ferran +7 more
TL;DR: This report maps descriptively the early differentiation and apparent migratory dispersion of mouse subpallial somatostatin-expressing (Sst) cells from E10.5 onward, comparing their topography with the expression patterns of the genes Dlx5, Gbx2, Lhx7-8, Nkx2.1, Hmx3, and Shh, which variously label parts of the subpallium.
Journal ArticleDOI
Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex
TL;DR: The aim of this review is to summarize the current knowledge of the interplay between microenvironmental signals and cell autonomous programs that drive cortical interneuron porduction, tangential migration, and intergration in the developing cerebral cortex.
Journal ArticleDOI
Altered expression of developmental regulators of parvalbumin and somatostatin neurons in the prefrontal cortex in schizophrenia
TL;DR: The over-expression of a subset of molecular markers with distinct roles in the pre- and postnatal development of parvalbumin and somatostatin neurons might reflect compensatory mechanisms to sustain the development of these neurons in the face of other insults.
References
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Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
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Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
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Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.