Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Transcriptional landscape of the prenatal human brain
Jeremy A. Miller,Songlin Ding,Susan M. Sunkin,Kimberly A. Smith,Lydia Ng,Aaron Szafer,Amanda Ebbert,Zackery L. Riley,Joshua J. Royall,Kaylynn Aiona,James M. Arnold,Crissa Bennet,Darren Bertagnolli,Krissy Brouner,Stephanie Butler,Shiella Caldejon,Anita Carey,Christine Cuhaciyan,Rachel A. Dalley,Nick Dee,Tim A. Dolbeare,Benjamin A.C. Facer,David Feng,Tim P. Fliss,Garrett Gee,Jeff Goldy,Lindsey Gourley,Benjamin W. Gregor,Guangyu Gu,Robert Howard,Jayson M. Jochim,Chihchau L. Kuan,Christopher Lau,Changkyu Lee,Felix Lee,Tracy Lemon,Phil Lesnar,Bergen McMurray,Naveed Mastan,Nerick Mosqueda,Theresa Naluai-Cecchini,Nhan Kiet Ngo,Julie Nyhus,Aaron Oldre,Eric Olson,Jody Parente,Patrick D. Parker,Sheana Parry,Allison Stevens,Mihovil Pletikos,Melissa Reding,Kate Roll,David Sandman,Melaine Sarreal,Sheila Shapouri,Nadiya V. Shapovalova,Elaine H. Shen,Nathan Sjoquist,Clifford R. Slaughterbeck,Michael W. Smith,Andy J. Sodt,Derric Williams,Lilla Zöllei,Bruce Fischl,Mark Gerstein,Daniel H. Geschwind,Ian A. Glass,Michael Hawrylycz,Robert F. Hevner,Hao Huang,Allan R. Jones,James A. Knowles,Pat Levitt,John W. Phillips,Nenad Sestan,Paul Wohnoutka,Chinh Dang,Amy Bernard,John G. Hohmann,Ed S. Lein +79 more
TL;DR: An anatomically comprehensive atlas of the mid-gestational human brain is described, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions.
Journal ArticleDOI
Conserved cell types with divergent features in human versus mouse cortex.
Rebecca D. Hodge,Trygve E. Bakken,Jeremy A. Miller,Kimberly A. Smith,Eliza Barkan,Lucas T. Graybuck,Jennie L. Close,Brian Long,Nelson Johansen,Osnat Penn,Zizhen Yao,Jeroen Eggermont,Thomas Höllt,Thomas Höllt,Boaz P. Levi,Soraya I. Shehata,Brian D. Aevermann,Allison Beller,Darren Bertagnolli,Krissy Brouner,Tamara Casper,Charles Cobbs,Rachel A. Dalley,Nick Dee,Songlin Ding,Richard G. Ellenbogen,Olivia Fong,Emma Garren,Jeff Goldy,Ryder P. Gwinn,Daniel Hirschstein,C. Dirk Keene,Mohamed Keshk,Andrew L. Ko,Andrew L. Ko,Kanan Lathia,Ahmed Mahfouz,Ahmed Mahfouz,Zoe Maltzer,Medea McGraw,Thuc Nghi Nguyen,Julie Nyhus,Jeffrey G. Ojemann,Jeffrey G. Ojemann,Aaron Oldre,Sheana Parry,Shannon Reynolds,Christine Rimorin,Nadiya V. Shapovalova,Saroja Somasundaram,Aaron Szafer,Elliot R. Thomsen,Michael Tieu,Gerald Quon,Richard H. Scheuermann,Richard H. Scheuermann,Rafael Yuste,Susan M. Sunkin,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,David Feng,Lydia Ng,Amy Bernard,Michael Hawrylycz,John W. Phillips,Bosiljka Tasic,Hongkui Zeng,Allan R. Jones,Christof Koch,Ed Lein +69 more
TL;DR: RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.
Journal ArticleDOI
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Blue B. Lake,Rizi Ai,Gwendolyn E. Kaeser,Gwendolyn E. Kaeser,Neeraj Salathia,Yun C. Yung,Rui Liu,Andre Wildberg,Derek Gao,Ho-Lim Fung,Song Chen,Raakhee Vijayaraghavan,Julian Wong,Allison Chen,Xiaoyan Sheng,Fiona Kaper,Richard Shen,Mostafa Ronaghi,Jian-Bing Fan,Wei Wang,Jerold Chun,Kun Zhang +21 more
TL;DR: A scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from a postmortem brain, generating 3227 sets of single-neuron data from six distinct regions of the cerebral cortex demonstrates a robust and scalable method for identifying and categorizing single nuclear transcriptomes.
Journal ArticleDOI
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.
Blue B. Lake,Song Chen,Brandon C. Sos,Jean Fan,Gwendolyn E. Kaeser,Yun C. Yung,Thu Elizabeth Duong,Derek Gao,Jerold Chun,Peter V. Kharchenko,Kun Zhang +10 more
TL;DR: Improved high-throughput methods for single-nucleus droplet-based sequencing and single-cell transposome hypersensitive site sequencing are reported, which revealed regulatory elements and transcription factors that underlie cell-type distinctions and mapped disease-associated risk variants to specific cellular populations, which provided insights into normal and pathogenic cellular processes in the human brain.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
References
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OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
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Pax6 controls radial glia differentiation in the cerebral cortex
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