Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Book ChapterDOI
Telencephalic Tissue Formation in 3D Stem Cell Culture
TL;DR: The generation of telencephalic tissues from human pluripotent stem cells (PSCs) provides a new experimental platform for biomedical research, such as disease modeling, drug screening, and cell-based transplantation therapy.
Posted ContentDOI
Comparative Features of Calretinin, Calbindin and Parvalbumin Expressing Interneurons in Mouse and Monkey Primary Visual and Frontal Cortices
TL;DR: In this paper , the authors quantified the distribution and somato-dendritic morphology of interneurons expressing one or more of the calcium binding proteins (CaBPs) calretinin (CR), calbindin (CB) and/or parvalbumin (PV) in mouse (Mus musculus) versus rhesus monkey (Macaca mulatta).
Journal ArticleDOI
Human brains teach us a surprising lesson
Melissa G. McKenzie,Gord Fishell +1 more
TL;DR: A population of interneurons that migrate to the cortex during infancy to establish inhibitory circuits is identified, indicating that the cortex is able to function only when excitatory and inhibitory activities in the brain are balanced.
Posted ContentDOI
The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts
Jaeyeon Kim,Kadellyn Sandoval,Aunoy Poddar,Julia S. Chu,Emma C. Horton,Theresa Bartels,Christian M Wood,David H. Rowitch,Hosung Park and Ji-Hwan Kim,Chet C. Sherwood,Boris W. Kramer,Angela C. Roberts,Pablo J. Ross,Duan Xu,Nicola J. Robertson,Peng Ji,Elizabeth A. Maga,Mercedes F. Paredes +17 more
TL;DR: In this paper , the authors demonstrate that neonatal gyrencephalic brains harbor an expanded subventricular zone, termed the Arc, defined by tiered arrangement of doublecortin (DCX)-expressing neuroblasts and vascular enrichment at the ventricular wall.
Journal ArticleDOI
Auditory and visual system white matter is differentially impacted by normative aging in macaques
Daniel T. Gray,Nicole M. De La Peña,Lavanya Umapathy,Sara N. Burke,James R. Engle,Theodore P. Trouard,Carol A. Barnes +6 more
TL;DR: The results suggest that age-related sensory processing deficits in part result from factors that impact the condition of specific white matter tracts, and not from general decreases in connectivity between sensory brain regions.
References
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
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Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
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