Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
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Using organoids to study human brain development and evolution.
TL;DR: A review of the potential of cerebral organoids to model and study human brain development and evolution can be found in this article, where the authors discuss the progress and current challenges in their use for reproducing specific human neurodevelopmental processes.
Posted ContentDOI
Parallel RNA and DNA analysis after Deep-sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain
August Yue Huang,August Yue Huang,August Yue Huang,Pengpeng Li,Pengpeng Li,Pengpeng Li,Rachel E. Rodin,Sonia N. Kim,Yanmei Dou,Connor J. Kenny,Connor J. Kenny,Connor J. Kenny,Shyam K. Akula,Rebecca D. Hodge,Trygve E. Bakken,Jeremy A. Miller,Ed Lein,Peter J. Park,Eunjung Lee,Eunjung Lee,Eunjung Lee,Christopher A. Walsh +21 more
TL;DR: New technology to analyze both DNA mutations and RNA gene expression patterns in single cells from human postmortem brain are developed, allowing us to define clonal patterns among different types of human brain neurons, gaining the first direct insight into how they form.
Journal ArticleDOI
Seeking clues in brain development to explain the extraordinary evolution of language in humans
TL;DR: In this review, four areas of development predicted to be of importance are explored, including an increase in size and gyrification of the cerebral cortex, increased connectivity between functional areas of the cortex, an expanded role for the subplate in guiding this process, and changes in synapse formation.
Posted ContentDOI
Vascular-Derived SPARC and SerpinE1 Regulate Interneuron Tangential Migration and Accelerate Functional Maturation of Human Stem Cell-Derived Interneurons
Matthieu Genestine,Daisy Ambriz,Gregg W. Crabtree,Anna Molotkova,Michael Quintero,Angeliki Mela,Saptarshi Biswas,Peter Canoll,Gunnar Hargus,Dritan Agalliu,Joseph A. Gogos,Edmund Au +11 more
TL;DR: Two endothelial cell-derived paracrine factors are identified that enhance interneuron migration in mouse MGE explants and organotypic cultures and suggest a critical role for CNS vasculature in regulating interneurons developmental maturation in both mice and humans.
References
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
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