Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
Citations
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Brain circuit pathology in Down syndrome: from neurons to neural networks
TL;DR: This review summarizes the state of the art regarding the electrical properties of the DS brain, starting from individual neurons and culminating in signal processing in whole neuronal networks.
Journal ArticleDOI
BRN2 as a key gene drives the early primate telencephalon development
Xiaoqin Zhu,Yicheng Guo,Chu Chu,Dahai Liu,K. Duan,Yu Yin,Chenyang Si,Yu Kang,Jun Yao,Xuewei Du,Junliang Li,Shumei Zhao,Zongyong Ai,Qingyuan Zhu,Weizhi Ji,Yuyu Niu,Tianqing Li +16 more
TL;DR: Findings reveal a previously unknown mechanism that BRN2, a conserved gene, drives early primate telencephalon development by gaining novel mechanistic functions.
Dissertation
The role of SATB1 in medial ganglionic eminence-derived cortical interneuron differentiation
TL;DR: The in vivo role of SATB1 in cortical interneuron terminal differentiation is investigated and the findings provide a basis for understanding the terminal differentiation of interneurons in the mammalian cortex.
Journal ArticleDOI
Neural development: Tracing interneuron roots.
TL;DR: The results of two new studies suggest that human cortical interneurons predominantly originate in subcortical regions, and that these regions are dominated by the hippocampus and amygdala.
Journal ArticleDOI
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion
Yifei Yang,Sam A. Booker,James M. Clegg,Idoia Quintana-Urzainqui,Anna Sumera,Zrinko Kozic,Owen Dando,Martin Lorenzo,Yann Herault,Peter C. Kind,David Price,Thomas Pratt +11 more
TL;DR: In this article , a subset of human interneurons (INs) first appeared at GW23 with enriched expression of a large fraction of risk factor transcripts including those expressed from the 16p11.2 locus.
References
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Journal ArticleDOI
Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
Journal ArticleDOI
Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
TL;DR: The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts.
Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
TL;DR: This work finds that OSVZ radial glia-like cells have a long basal process but, surprisingly, are non-epithelial as they lack contact with the ventricular surface, and demonstrates that these cells can undergo proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cells that can proliferate further.