Journal ArticleDOI
Subcortical origins of human and monkey neocortical interneurons
Tong Ma,Congmin Wang,Lei Wang,Lei Wang,Xing Zhou,Miao Tian,Qiangqiang Zhang,Yue Zhang,Jiwen Li,Zhidong Liu,Yuqun Cai,Fang Liu,Yan You,Chao Chen,Kenneth Campbell,Hongjun Song,Lan Ma,John L.R. Rubenstein,Zhengang Yang +18 more
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TLDR
It is proposed that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon, and this work reveals that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping the understanding of the origin and classification ofPrimate neocortex.Abstract:
In primates, the developmental origin of neocortical interneurons is controversial. Here the authors map out expression patterns of key transcription factors in the developing human and monkey brain and reveal that, just as in rodents, the majority of cortical GABAergic neurons originate from the ganglionic eminences.read more
Citations
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GABAergic interneuron transplants to study development and treat disease.
TL;DR: It is reviewed how this remarkable ability to integrate post-transplant is being applied to the development of cell-based therapies for a variety of CNS disorders.
Journal ArticleDOI
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia
Zhicheng Shao,Zhicheng Shao,Haneul Noh,Haneul Noh,Woong Bin Kim,Peiyan Ni,Peiyan Ni,Christine T. O. Nguyen,Sarah E. Cote,Elizabeth Noyes,Joyce Zhao,Teagan Parsons,James M. Park,Kelvin Zheng,Joshua J. Park,Joseph T. Coyle,Daniel R. Weinberger,Richard E. Straub,Karen F. Berman,Jose A. Apud,Dost Öngür,Bruce M. Cohen,Donna L. McPhie,Judith L. Rapoport,Roy H. Perlis,Thomas A. Lanz,Hualin Simon Xi,Changhong Yin,Weihua Huang,Teruyoshi Hirayama,Teruyoshi Hirayama,Emi Fukuda,Takeshi Yagi,Sulagna Ghosh,Kevin Eggan,Hae Young Kim,Leonard M. Eisenberg,Alexander A. Moghadam,Patric K. Stanton,Jun-Hyeong Cho,Sangmi Chung,Sangmi Chung +41 more
TL;DR: Findings reveal an intrinsic abnormality in schizophrenia cINs in the absence of any circuit-driven pathology and demonstrate the utility of homogenous and functional populations of a relevant neuronal subtype for probing pathogenesis mechanisms during development.
Journal ArticleDOI
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Carol C.L. Chen,Shriya Deshmukh,Selin Jessa,Selin Jessa,Djihad Hadjadj,Véronique Lisi,Augusto Faria Andrade,Damien Faury,Wajih Jawhar,Rola Dali,Hiromichi Suzuki,Manav Pathania,Manav Pathania,Deli A,Frank Dubois,Eleanor Woodward,Steven Hébert,Steven Hébert,Marie Coutelier,Marie Coutelier,Jason Karamchandani,Steffen Albrecht,Sebastian Brandner,Nicolas De Jay,Nicolas De Jay,Tenzin Gayden,Andrea Bajic,Ashot S. Harutyunyan,Dylan M. Marchione,Leonie G. Mikael,Nikoleta Juretic,Michele Zeinieh,Caterina Russo,Nicola Maestro,Angelia V. Bassenden,Peter Hauser,József Virga,László Bognár,Almos Klekner,Michal Zapotocky,Ales Vicha,Lenka Krskova,Katerina Vanova,Josef Zamecnik,David Sumerauer,Paul G Ekert,David S. Ziegler,David S. Ziegler,Benjamin Ellezam,Mariella G. Filbin,Mathieu Blanchette,Jordan R. Hansford,Dong Anh Khuong-Quang,Albert M. Berghuis,Alexander G. Weil,Benjamin A. Garcia,Livia Garzia,Livia Garzia,Stephen C. Mack,Rameen Beroukhim,Rameen Beroukhim,Keith L. Ligon,Keith L. Ligon,Michael D. Taylor,Pratiti Bandopadhayay,Pratiti Bandopadhayay,CM Kramm,Stefan M. Pfister,Stefan M. Pfister,Andrey Korshunov,Andrey Korshunov,Dominik Sturm,Dominik Sturm,David T.W. Jones,Paolo Salomoni,Claudia L. Kleinman,Claudia L. Kleinman,Nada Jabado,Nada Jabado +78 more
TL;DR: It is shown that 50% of G34R/V tumors bear activating PDGFRA mutations that display strong selection pressure at recurrence, and these results open novel research avenues in deadly tumors.
Journal ArticleDOI
Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia
David W. Volk,David A. Lewis +1 more
TL;DR: This review article proposes a strategy to investigate how alterations in the expression of developmental regulators of subpopulations of cortical GABA neurons may contribute to the pathogenesis of cortical inhibitory neuron dysfunction and consequently cognitive impairments in schizophrenia.
Journal ArticleDOI
Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition
Ahmed Gilani,Muhammad Omar Chohan,Melis Inan,Scott A. Schobel,Nashid H. Chaudhury,Samuel Paskewitz,Nao Chuhma,Sara B. Glickstein,Robert J. Merker,Qing Xu,Scott A. Small,Stewart A. Anderson,Margaret Elizabeth Ross,Holly Moore +13 more
TL;DR: Functional links between hippocampal GABA interneuron deficits and psychosis-relevant dopaminergic and cognitive phenotypes are established, and support a rationale for targeting limbic corticalinterneuron function in the prevention and treatment of schizophrenia.
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Journal ArticleDOI
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
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Journal ArticleDOI
Neurogenic radial glia in the outer subventricular zone of human neocortex
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