The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
Citations
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Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense
TL;DR: These novel functions of p53 help to align metabolic processes with the proliferation and energy status, to maintain optimal mode of glucose metabolism and to boost the energy efficient mitochondrial respiration in response to ATP deficiency.
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fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma
Yunxia Ge,Xiaodan Yan,Yiguang Jin,Xinyu Yang,Xiang Yu,Liqing Zhou,Sichong Han,Qipeng Yuan,Ming Yang +8 more
TL;DR: It is speculated that the miR-192/-204-HOTTIP axis may interrupt HCC glutaminolysis through GLS1 inhibition, which is a crucial hallmark of cancer cells and significantly inhibited cell viability after silencingGLS1, in this study.
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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
Colin A. Flaveny,Kristine Griffett,Bahaa El-Dien M. El-Gendy,Melissa Kazantzis,Monideepa Sengupta,Antonio L. Amelio,Arindam Chatterjee,John K. Walker,Laura A. Solt,Theodore M. Kamenecka,Thomas P. Burris,Thomas P. Burris +11 more
TL;DR: In cancer cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression and suggest that LXR inverse agonists may be an effective cancer treatment approach.
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Mitochondrial metabolism and cancer.
TL;DR: The accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation is reviewed.
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Phosphorescent Polymeric Thermometers for In Vitro and In Vivo Temperature Sensing with Minimized Background Interference
Zejing Chen,Kenneth Yin Zhang,Xiao Tong,Yahong Liu,Changyong Hu,Shujuan Liu,Qi Yu,Qiang Zhao,Wei Huang,Wei Huang +9 more
TL;DR: In this paper, a dual-emissive polymeric thermometer has been developed by incorporating two long-lived phosphorescent iridium(III) complexes into an acrylamide-based thermosensitive polymer.
References
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High frequency of mutations of the PIK3CA gene in human cancers
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