The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
Reads0
Chats0
TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
Citations
More filters
Journal ArticleDOI
Multicolor two-photon imaging of endogenous fluorophores in living tissues by wavelength mixing
Chiara Stringari,Lamiae Abdeladim,Guy Malkinson,Pierre Mahou,Xavier Solinas,Isabelle Lamarre,Sébastien Brizion,Jean-Baptiste Galey,Willy Supatto,Renaud Legouis,Ana-Maria Pena,Emmanuel Beaurepaire +11 more
TL;DR: Efficient and simultaneous multicolor two-photon excitation of endogenous fluorophores with absorption spectra spanning the 750–1040 nm range is reported, using wavelength mixing to permit an efficient simultaneous imaging of the metabolic coenzymes NADH and FAD in living tissues.
Journal ArticleDOI
Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.
TL;DR: This review focuses on the contributions of mitochondria, lipid and amino acid metabolism to the metastatic process, including succinate, fumarate, and d-2-hydroxyglutarate that control energy production, biosynthesis and the redox state.
Journal ArticleDOI
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Alejandro Vazquez-Martin,Bruna Corominas-Faja,Sílvia Cufí,Luciano Vellon,Cristina Oliveras-Ferraros,Octavio J. Menendez,Jorge Joven,Ruth Lupu,Javier A. Menendez +8 more
TL;DR: The mitochondrial H+-ATP synthase and the ACACA/FASN-driven lipogenic switch are newly characterized as instrumental metabolic events that, by coupling the Warburg effect to anabolic metabolism, enable de-differentiation during the reprogramming of somatic cells to iPS cells.
Journal ArticleDOI
An RNA Interference Screen Identifies Metabolic Regulators NR1D1 and PBP as Novel Survival Factors for Breast Cancer Cells with the ERBB2 Signature
Antonis Kourtidis,Ritu Jain,Richard D Carkner,Cheryl Eifert,M. Julia Brosnan,Douglas S. Conklin +5 more
TL;DR: It is shown that NR1D1 and PBP act through a common pathway in upregulating several genes in the de novo fatty acid synthesis network, which is highly active in ERBB2-positive breast cancer cells.
Journal ArticleDOI
Abemaciclib, a Selective CDK4/6 Inhibitor, Enhances the Radiosensitivity of Non–Small Cell Lung Cancer In Vitro and In Vivo
Sarwat Naz,Anastasia L. Sowers,Rajani Choudhuri,Maria F Wissler,Janet Gamson,Askale Mathias,John A. Cook,James B. Mitchell +7 more
TL;DR: Abemaciclib in combination with IR enhances NSCLC radiosensitivity in preclinical models, potentially providing a novel biomarker-driven combination therapeutic strategy for patients withNSCLC.
References
More filters
Journal ArticleDOI
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
TL;DR: The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
Journal ArticleDOI
Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
Journal ArticleDOI
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
Journal ArticleDOI
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.