The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
Citations
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Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine.
TL;DR: This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.
Journal ArticleDOI
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways†
Jun-ichi Hanai,Nathaniel Doro,Atsuo T. Sasaki,Atsuo T. Sasaki,Susumu Kobayashi,Lewis C. Cantley,Lewis C. Cantley,Pankaj Seth,Vikas P. Sukhatme +8 more
TL;DR: It is shown that ACL knockdown promotes apoptosis and differentiation, leading to the inhibition of tumor growth in vivo, and it is found that statins, inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, which act downstream of ACL in the cholesterol synthesis pathway, dramatically enhance the anti‐tumor effects of ACL inhibition, even regressing established tumors.
Journal ArticleDOI
Myc: Maestro of MicroRNAs
Thi V. Bui,Joshua T. Mendell +1 more
TL;DR: This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis.
Book ChapterDOI
Metabolic Regulation of Apoptosis in Cancer
TL;DR: How cellular apoptosis is regulated and how metabolism can influence the signaling pathways leading to apoptosis are reviewed, especially focusing on how glucose and lipid metabolism are altered in cancer cells and how these alterations can impact the apoptotic pathways.
Journal ArticleDOI
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Jian-kang Jiang,Matthew B. Boxer,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Min Shen,Amanda P. Skoumbourdis,Noel Southall,Henrike Veith,William Leister,Christopher P. Austin,Hee-Won Park,Hee-Won Park,James Inglese,Lewis C. Cantley,Lewis C. Cantley,Douglas S. Auld,Craig J. Thomas +16 more
TL;DR: These agents represent the second reported chemotype for activation of PKM2 based upon a substituted thieno-pyrrole-based scaffold and are described as a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells.
References
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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
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TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
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High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.