The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
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The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells.
TL;DR: The finding that several mechanical properties of cancer cells and their microenvironment influence each other and continuously contribute to tumor growth and cancer progression is explained in physical terms by applying physical principles on living cells regardless of their complexity and individual differences of cancer types.
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Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer
Andréia Vasconcelos-dos-Santos,Isadora A. Oliveira,Miguel C. Lucena,Natalia Rodrigues Mantuano,Stephen A. Whelan,Wagner B. Dias,Adriane R. Todeschini +6 more
TL;DR: This review describes three classes of glycosylation, O-GlcNAcylation, N-linked, and mucin type O-linked glycosYLation, involved in tumor progression, their biosynthesis and highlights the available inhibitors as potential anti-tumor drugs.
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Ketogenic diets: from cancer to mitochondrial diseases and beyond
Ana F. Branco,André F. Ferreira,Rui F. Simões,Silvia Magalhães-Novais,Cheryl Zehowski,Elisabeth Cope,Ana Marta Ribeiro da Silva,Daniela Pereira,Vilma A. Sardão,Teresa Cunha-Oliveira +9 more
TL;DR: The employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases.
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Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells
Bai Cui,Yuanyuan Luo,Pengfei Tian,Fei Peng,Jinxin Lu,Jinxin Lu,Yongliang Yang,Qitong Su,Bing Liu,Jiachuan Yu,Xi Luo,Liu Yin,Wei Cheng,Fan An,Bin He,Dapeng Liang,Sijin Wu,Peng Chu,Luyao Song,Xinyu Liu,Huandong Luo,Jie Xu,Yujia Pan,Yang Wang,Dangsheng Li,Peng Huang,Qingkai Yang,Lingqiang Zhang,Binhua P. Zhou,Suling Liu,Guowang Xu,Eric Lam,Keith W. Kelley,Quentin Liu,Quentin Liu +34 more
TL;DR: It is found that a chronic stress–induced cancer stem-like phenotype could be reversed by vitamin C, and the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
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Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
TL;DR: This work represents the first comprehensive study on lactate depletion and offers a simple yet effective strategy to overcome ammonia and pCO2 accumulation that could arise in certain cultures due to early depletion of lactate.
References
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Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
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Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
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High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.