The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
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The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.
TL;DR: A primordial mitotic role for the α catalytic AMPK subunit in the eukaryotic evolutionary process as it may ensure, at the cell level, an exquisite coordination between sensing of energy resources and the fundamental biological process of genome division.
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Polyhydroxyalkanoate (PHA): applications in drug delivery and tissue engineering.
Enas Elmowafy,Abdalla Abdal-hay,Athanasios Skouras,Athanasios Skouras,Mattia Tiboni,Luca Casettari,Vincenzo Guarino +6 more
TL;DR: This review provides an overview of the polyhydroxyalkanoates biosynthesis and their possible applications in drug delivery in the range of micro- and nano-size and the possible Applications in tissue engineering are covered considering macro- and microporous scaffolds and extracellular matrix analogs.
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TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells
TL;DR: The pro-inflammatory cytokines TNFα and IL-17 may contribute to this effect by stimulating glycolysis and growth factor production in colorectal cancer cells by synergistically stimulated production by HT-29 cells of a growth factor that simulated proliferation/survival of NIL8 fibroblastic cells.
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Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism
Yan Ding,Zixing Liu,Shruti Desai,Yuhua Zhao,Hao Liu,Lewis K. Pannell,Hong Yi,Elizabeth R. Wright,Laurie B. Owen,Windy Dean-Colomb,Øystein Fodstad,Jianrong Lu,Susan P. LeDoux,Glenn L. Wilson,Ming Tan +14 more
TL;DR: A novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples is described and it is found that ErBB2 translocates into mitochondria through the association with mtHSP70, which negatively regulates mitochondrial respiratory functions.
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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply.
Gilles A. Spoden,Ursula Rostek,Stefan Lechner,Maria C. Mitterberger,Sybille Mazurek,Werner Zwerschke +5 more
TL;DR: It is demonstrated that, at normal blood glucose concentrations, peptide aptamer-mediated inhibition of M2-PK induces a significant decrease of the population doubling and cell proliferation rate as well as a increase in cell size, whereas under glucose restriction an increase in PDL and celliferation rates but a decrease incell size was observed.
References
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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
TL;DR: The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
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Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
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High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.