The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
Citations
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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
Chen Zhao,Douglas Yasumura,Xiyan Li,Michael T. Matthes,Marcia Lloyd,Gregory Nielsen,Kelly Ahern,Michael Snyder,Dean Bok,Joshua L. Dunaief,Matthew M. LaVail,Douglas Vollrath +11 more
TL;DR: An in vivo response of the mature RPE to diverse stressors that prolongs RPE cell survival at the expense of epithelial attributes and photoreceptor function is revealed.
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Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.
Xue Gao,Shuhai Lin,Shuhai Lin,Feng Ren,Jin-Tao Li,Jiajia Chen,Chuan Bo Yao,Hong-Bin Yang,Shu Xia Jiang,Guo Quan Yan,Di Wang,Yi Wang,Ying Liu,Zongwei Cai,Ying-Ying Xu,Jing Chen,Wenqiang Yu,Pengyuan Yang,Qun-Ying Lei +18 more
TL;DR: This study demonstrates that acetate, in addition to its ability to induce fatty acid synthesis as an immediate metabolic precursor, also functions as an epigenetic metabolite to promote cancer cell survival under hypoxic stress.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
Wei Yan,Xiwei Wu,Weiying Zhou,Weiying Zhou,Miranda Y. Fong,Miranda Y. Fong,Minghui Cao,Juan Liu,Xiaojing Liu,Chih Hong Chen,Oluwole Fadare,Donald P. Pizzo,Jiawen Wu,Liang Liu,Xuxiang Liu,Andrew R. Chin,Andrew R. Chin,Xiubao Ren,Yuan Chen,Jason W. Locasale,Shizhen Emily Wang +20 more
TL;DR: It is shown that exosomal miR-105 derived from cancer cells confers metabolic plasticity in recipient cancer-associated fibroblasts to adapt to nutrient-replete and -deplete conditions, thereby sustaining tumour growth.
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Distinctive properties of metastasis-initiating cells
Toni Celià-Terrassa,Yibin Kang +1 more
TL;DR: Better understanding of the molecular and cellular hallmarks of MICs will facilitate the development and deployment of novel therapeutic strategies.
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Monocarboxylate transporters in the brain and in cancer
Jhudit Pérez-Escuredo,Vincent F. Van Hée,Martina Sboarina,Jorge Falces,Valéry Payen,Luc Pellerin,Pierre Sonveaux +6 more
TL;DR: Because MCTs gate the activities of lactate, drugs targeting these transporters have been developed that could constitute new anticancer treatments and are part of a Special Issue entitled: Mitochondrial Channels.
References
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Journal ArticleDOI
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
TL;DR: The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
Journal ArticleDOI
Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
Journal ArticleDOI
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
Journal ArticleDOI
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.