The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
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Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.
D J Roberts,Shigeki Miyamoto +1 more
TL;DR: Recent advances in understanding the protective role ofHK-II are summarized, controlling cellular growth, preventing mitochondrial death pathway and enhancing autophagy, with a particular focus on the interaction between HK-II and Akt/mTOR pathway to integrate metabolic status with the control of cell survival.
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Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment.
TL;DR: It is proposed that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy.
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ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
Guoliang Qing,Bo Li,Annette Vu,Nicolas Skuli,Nicolas Skuli,Zandra E. Walton,Xueyuan Liu,Patrick A. Mayes,David R. Wise,Craig B. Thompson,John M. Maris,Michael D. Hogarty,M. Celeste Simon,M. Celeste Simon +13 more
TL;DR: Mechanisms whereby Myc sensitizes cells to apoptosis are revealed, and ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics are validated.
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Activity-based protein profiling for biochemical pathway discovery in cancer
TL;DR: Activity-based profiling platforms enable both the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumour cells and can provide insight into the metabolic and signalling pathways that support cancer pathogenesis and illuminate new strategies for disease diagnosis and treatment.
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Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
Na Xie,Zheng Tan,Zheng Tan,Sami Banerjee,Huachun Cui,Jing Ge,Rui-Ming Liu,Karen Bernard,Victor J. Thannickal,Gang Liu +9 more
TL;DR: The data support the novel concept of glycolytic reprogramming in the pathogenesis of lung fibrosis and provide proof-of-concept that targeting this pathway may be efficacious in treating fibrotic disorders, such as idiopathic pulmonary fibrosis.
References
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