The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
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TLDR
This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 3526 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Lipid biosynthesis.read more
Citations
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Is metabolic rate a universal 'pacemaker' for biological processes?
TL;DR: It is argued that a comprehensive understanding of the pace of life must include how biological activities depend on both energy and information and their environmentally sensitive interaction, supported by extensive evidence showing that hormones and other regulatory factors and signalling systems coordinate the processes of growth, metabolism and food intake in adaptive ways that are responsive to an organism's internal and external conditions.
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Noga Ron-Harel,Daniel Ditzel Santos,Daniel Ditzel Santos,Jonathan M. Ghergurovich,Peter T. Sage,Peter T. Sage,Anita Reddy,Scott B. Lovitch,Scott B. Lovitch,Noah Dephoure,F. Kyle Satterstrom,Michal Sheffer,Jessica B. Spinelli,Steven P. Gygi,Joshua D. Rabinowitz,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +17 more
TL;DR: It is shown that naive CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling that generates specialized mitochondria with enhanced one-carbon metabolism that is critical for T-cell activation and survival.
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Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis.
Stephanos Pavlides,Iset Medina Vera,Ricardo Gandara,Sharon Sneddon,Richard G. Pestell,Isabelle Mercier,Ubaldo E. Martinez-Outschoorn,Diana Whitaker-Menezes,Anthony Howell,Federica Sotgia,Michael P. Lisanti +10 more
TL;DR: A new two-compartment model for understanding tumor metabolism is proposed, which adds a novel stromal twist to two very well-established cancer paradigms: aerobic glycolysis and autophagy.
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Single cell optical imaging and spectroscopy.
Anthony S. Stender,Kyle Marchuk,Chang Liu,Suzanne Sander,Matthew W. Meyer,Emily A. Smith,Bhanu Neupane,Gufeng Wang,Junjie Li,Ji-Xin Cheng,Bo Huang,Ning Fang +11 more
TL;DR: A review of the key advances that have occurred in the past several years in the field of single cell optical imaging to highlight the types of findings that are possible at the nexus of microscopy, nanoprobes, and live cells.
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mTOR signaling in cellular and organismal energetics.
Verena Albert,Michael N. Hall +1 more
TL;DR: This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.
References
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