The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
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Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
Nishant Agrawal,Mitchell J. Frederick,Curtis R. Pickering,Chetan Bettegowda,Kyle Chang,Ryan J. Li,Carole Fakhry,Tong Xin Xie,Jiexin Zhang,Jing Wang,Nianxiang Zhang,Adel K. El-Naggar,Samar A. Jasser,John N. Weinstein,Lisa R. Trevino,Jennifer Drummond,Donna M. Muzny,Yuanqing Wu,Laura D. Wood,Ralph H. Hruban,William H. Westra,Wayne M. Koch,Joseph A. Califano,Joseph A. Califano,Richard A. Gibbs,Richard A. Gibbs,David Sidransky,Bert Vogelstein,Victor E. Velculescu,Nickolas Papadopoulos,David A. Wheeler,Kenneth W. Kinzler,Jeffrey N. Myers +32 more
TL;DR: To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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MicroRNA control of signal transduction.
TL;DR: New evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-β, WNT, Notch and epidermal growth factor, which serves as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
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Balancing forces: architectural control of mechanotransduction
TL;DR: Sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
References
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SHARP is a novel component of the Notch/RBP‐Jκ signalling pathway
Franz Oswald,Ulrike Kostezka,Kathy Astrahantseff,Soizic Bourteele,Karin Dillinger,Ulrich Zechner,Leopold Ludwig,Monika Wilda,Horst Hameister,Walter Knöchel,Susanne Liptay,Roland M. Schmid +11 more
TL;DR: A model in which SHARP is a novel component of the HDAC corepressor complex, recruited by RBP‐Jκ to repress transcription of target genes in the absence of activated Notch is proposed.
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Notch activity acts as a sensor for extracellular calcium during vertebrate left–right determination
Angel Raya,Yasuhiko Kawakami,Concepción Rodríguez-Esteban,Marta Ibañes,Diego Rasskin-Gutman,Joaquín Rodríguez-León,Dirk Büscher,José A. Feijó,José A. Feijó,Juan Carlos Izpisua Belmonte +9 more
TL;DR: A mathematical model describing the dynamics of the Notch signalling pathway during chick embryo gastrulation is presented, which reveals a complex and highly robust genetic network that locally activates Notch on the left side of Hensen's node.
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Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
Neetu Gupta-Rossi,Emmanuelle Six,Odile LeBail,Frédérique Logeat,Patricia Chastagner,Annie Olry,Alain Israël,Christel Brou +7 more
TL;DR: It is demonstrated that a new modification, a monoubiquitination, as well as clathrin-dependent endocytosis, is required for γ-secretase processing of a constitutively active Notch derivative, ΔE, which mimics the TNFα-converting enzyme–processing product.
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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
Emmanuelle Six,Delphine Ndiaye,Yacine Laabi,Christel Brou,Neetu Gupta-Rossi,Alain Israël,Frédérique Logeat +6 more
TL;DR: It is demonstrated here that the murine ligand Delta1 (Dll1) undergoes the same sequence of cleavages, in an apparently signal-independent manner, and that Dll1 is a substrate for regulated intramembrane proteolysis, and its intracellular region possibly fulfills a specific function in the nucleus.
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Instability of Hes7 protein is crucial for the somite segmentation clock.
Hiromi Hirata,Hiromi Hirata,Yasumasa Bessho,Hiroshi Kokubu,Yoshito Masamizu,Shuichi Yamada,Julian Lewis,Ryoichiro Kageyama +7 more
TL;DR: In mice expressing mutant Hes7 with a longer half-life but normal repressor activity, somite segmentation and oscillatory expression became severely disorganized after a few normal cycles of segmentation; instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock.
Related Papers (5)
Notch Signaling: Cell Fate Control and Signal Integration in Development
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more