The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
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Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
Nishant Agrawal,Mitchell J. Frederick,Curtis R. Pickering,Chetan Bettegowda,Kyle Chang,Ryan J. Li,Carole Fakhry,Tong Xin Xie,Jiexin Zhang,Jing Wang,Nianxiang Zhang,Adel K. El-Naggar,Samar A. Jasser,John N. Weinstein,Lisa R. Trevino,Jennifer Drummond,Donna M. Muzny,Yuanqing Wu,Laura D. Wood,Ralph H. Hruban,William H. Westra,Wayne M. Koch,Joseph A. Califano,Joseph A. Califano,Richard A. Gibbs,Richard A. Gibbs,David Sidransky,Bert Vogelstein,Victor E. Velculescu,Nickolas Papadopoulos,David A. Wheeler,Kenneth W. Kinzler,Jeffrey N. Myers +32 more
TL;DR: To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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MicroRNA control of signal transduction.
TL;DR: New evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-β, WNT, Notch and epidermal growth factor, which serves as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
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Balancing forces: architectural control of mechanotransduction
TL;DR: Sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
References
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High levels of Notch signaling down-regulate Numb and Numblike
TL;DR: Observations reveal a reciprocal negative regulation between Notch and Numb/Numblike, which may be of relevance for stabilizing asymmetric cell fate switches and for tumor development.
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Notch Signaling: Endocytosis Makes Delta Signal Better
TL;DR: Findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocyTosis of Delta and is required for efficient activation of Notch.
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A dominant-negative form of Serrate acts as a general antagonist of Notch activation
TL;DR: This work demonstrates that BD(G) can act as a general antagonist of both SERRATE and DELTA mediated NOTCH interactions, however, it retains the SERRate protein domain targeted by FRINGE, hence its antagonistic effects are restricted in the dorsal wing disc.
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Erratum: Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 (Nature (2000) 405 (966-970))
Stacey S. Huppert,A. Le,Eric H. Schroeter,Jeff S. Mumm,Meera T. Saxena,Laurie A. Milner,Raphael Kopan +6 more
TL;DR: In this article, the authors correct the article DOI: 35016111 and present a new version of the article with the same title: http://www.journals.informatics.edu.
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Oscillations, clocks and segmentation.
TL;DR: Interestingly, the oscillatory expression of Hes1 is observed in many cell types after serum stimulation, suggesting that this ultradian clock is not unique to presomitic mesoderm cells but widely distributed.
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more