The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Journal ArticleDOI
Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours
Kennosuke Karube,Daniel Martinez,Cristina Royo,Alba Navarro,Magda Pinyol,Maite Cazorla,Paola Castillo,Alexandra Valera,Anna Carrió,Dolors Costa,Dolors Colomer,Andreas Rosenwald,German Ott,Daniel Esteban,Eva Giné,Armando López-Guillermo,Elias Campo +16 more
TL;DR: The results indicate that NOTCH mutations are uncommon in FL but may occur in a subset of cases with distinctive, characteristic, clinicopathological features.
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Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain
Emmanuel Than-Trong,Emmanuel Than-Trong,Sara Ortica-Gatti,Sara Ortica-Gatti,Sébastien Mella,Sébastien Mella,Chirag Nepal,Alessandro Alunni,Alessandro Alunni,Laure Bally-Cuif,Laure Bally-Cuif +10 more
TL;DR: It is demonstrated that quiescence and stemness are molecularly distinct outputs of Notch3 signalling, and Hey1 is identified as a major NotCh3 effector controlling NSC stemness in the vertebrate adult brain.
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Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia
Nikos Kourtis,Charalampos Lazaris,Kathryn Hockemeyer,Juan Carlos Balandrán,Alejandra R. Jimenez,Jasper Mullenders,Jasper Mullenders,Yixiao Gong,Thomas Trimarchi,Kamala Bhatt,Hai Hu,Liza Shrestha,Alberto Ambesi-Impiombato,Michelle A. Kelliher,Elisabeth Paietta,Gabriela Chiosis,Monica L. Guzman,Adolfo A. Ferrando,Aristotelis Tsirigos,Iannis Aifantis +19 more
TL;DR: An integral crosstalk between mediators of oncogene and non-oncogene addiction is demonstrated and critical nodes of the heat shock response pathway that can be targeted therapeutically are revealed.
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Notch Signaling Promotes Growth and Invasion in Uveal Melanoma
Laura Asnaghi,Katayoon B. Ebrahimi,Karisa C. Schreck,Eli E. Bar,Michael L. Coonfield,W. Robert Bell,James T. Handa,Shannath L. Merbs,J. William Harbour,Charles G. Eberhart +9 more
TL;DR: It is suggested that Notch plays an important role in inducing proliferation and invasion in uveal melanoma and that inhibiting this pathway may be effective in preventing tumor growth and metastasis.
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Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models.
TL;DR: Experimental and computational models that help understand the operating principles of cell patterning driven by Notch signaling are reviewed and some recent evidence of mechanosensitivity in the Notch pathway in driving collective epithelial cell migration and cardiovascular morphogenesis is discussed.
References
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Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es,Marielle E. van Gijn,Orbicia Riccio,Maaike van den Born,Marc Vooijs,Harry Begthel,Miranda Cozijnsen,Sylvie Robine,Doug J. Winton,Freddy Radtke,Hans Clevers +10 more
TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.
Related Papers (5)
Notch Signaling: Cell Fate Control and Signal Integration in Development
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more