The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Journal ArticleDOI
Genetic interactions between Hepatocyte Nuclear Factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo
Charles Vanderpool,Erin E. Sparks,Kari A. Huppert,Maureen Gannon,Anna L. Means,Stacey S. Huppert +5 more
TL;DR: HNF‐6 and Notch signaling interact in vivo to control expression of downstream mediators essential to the normal development of the intrahepatic biliary system.
Posted ContentDOI
Human-specific NOTCH-like genes in a region linked to neurodevelopmental disorders affect cortical neurogenesis
Ian T. Fiddes,Gerrald A Lodewijk,Meghan Mooring,Colleen M. Bosworth,Adam D. Ewing,Gary L. Mantalas,Adam M. Novak,Anouk van den Bout,Alex Bishara,Jimi L. Rosenkrantz,Ryan Lorig-Roach,Andrew R. Field,Maximillian Haeussler,Lotte Russo,Aparna Bhaduri,Tomasz J. Nowakowski,Alex A. Pollen,Max L. Dougherty,Xander Nuttle,Marie-Claude Addor,Simon Zwolinski,Sol Katzman,Arnold R. Kriegstein,Evan E. Eichler,Sofie R. Salama,Frank M. J. Jacobs,David Haussler +26 more
TL;DR: Functional analysis reveals different alleles of NOTCH2NL have varying potencies to enhance Notch signaling by interacting directly with NOTCH receptors, and suggests the emergence of hominin-specific Notch2NL genes may have contributed to the rapid evolution of the larger hominIn neocortex accompanied by loss of genomic stability at the 1q21.1 locus and a resulting recurrent neurodevelopmental disorder.
Journal ArticleDOI
Molecular landscape of recurrent cervical cancer
TL;DR: The existing knowledge of disease relapse, accompanying challenges, and associated molecular players in CC is reviewed.
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Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression
Justin J. Grassmeyer,Malini Mukherjee,Jennifer deRiso,Casey Hettinger,Monica Bailey,Satrajit Sinha,Jane E. Visvader,Haotian Zhao,Eric Fogarty,Kameswaran Surendran +9 more
TL;DR: It is reported that the canonical Notch signaling pathway components, RBPJ and Presinilin1 and 2, are involved in patterning the mouse collecting duct cell fates by maintaining a balance between principal cell and intercalated cells fates.
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Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages
Tengfei Wang,Tengfei Wang,Zemin Xiang,Zemin Xiang,Ya Wang,Xi Li,Chongye Fang,Shuang Song,Chunlei Li,Haishuang Yu,Han Wang,Liang Yan,Shumei Hao,Xuanjun Wang,Xuanjun Wang,Jun Sheng,Jun Sheng +16 more
TL;DR: EGCG targets Notch to regulate the inflammatory response in the immediate early stage of EGCG treatment by shutting off Notch signaling and that the effect did not involve the 67-kDa laminin receptor, the common receptor for E GCG.
References
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es,Marielle E. van Gijn,Orbicia Riccio,Maaike van den Born,Marc Vooijs,Harry Begthel,Miranda Cozijnsen,Sylvie Robine,Doug J. Winton,Freddy Radtke,Hans Clevers +10 more
TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.
Related Papers (5)
Notch Signaling: Cell Fate Control and Signal Integration in Development
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more