The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
Journal ArticleDOI
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
Nishant Agrawal,Mitchell J. Frederick,Curtis R. Pickering,Chetan Bettegowda,Kyle Chang,Ryan J. Li,Carole Fakhry,Tong Xin Xie,Jiexin Zhang,Jing Wang,Nianxiang Zhang,Adel K. El-Naggar,Samar A. Jasser,John N. Weinstein,Lisa R. Trevino,Jennifer Drummond,Donna M. Muzny,Yuanqing Wu,Laura D. Wood,Ralph H. Hruban,William H. Westra,Wayne M. Koch,Joseph A. Califano,Joseph A. Califano,Richard A. Gibbs,Richard A. Gibbs,David Sidransky,Bert Vogelstein,Victor E. Velculescu,Nickolas Papadopoulos,David A. Wheeler,Kenneth W. Kinzler,Jeffrey N. Myers +32 more
TL;DR: To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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MicroRNA control of signal transduction.
TL;DR: New evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-β, WNT, Notch and epidermal growth factor, which serves as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
Journal ArticleDOI
Balancing forces: architectural control of mechanotransduction
TL;DR: Sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
References
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Journal ArticleDOI
Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.
Iva Greenwald,Geraldine Seydoux +1 more
TL;DR: The data suggest that self-association of the putative lin-12-encoded receptor leads to its activation, and that certain gain-of-function mutations result in ligand-independent activation.
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SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
TL;DR: It is shown that sup-17 encodes a member of the ADAM family of metalloproteases, which functions in Drosophila neurogenesis and the vertebrate ADAM10 protein, and that Sup-17 can act cell autonomously to facilitate lin-12 activity.
Journal ArticleDOI
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Toshihiko Masui,Qiaoming Long,Thomas M. Beres,Thomas M. Beres,Mark A. Magnuson,Raymond J. MacDonald +5 more
TL;DR: It is shown that early in pancreatic development, active PTF1a requires interaction with RBPJ, the vertebrate Suppressor of Hairless, within a stable trimeric DNA-binding complex (PTF1).
Journal ArticleDOI
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities
Ming-Tain Lai,Elizabeth Chen,Ming-Chih Crouthamel,Jillian DiMuzio-Mower,Min Xu,Qian Huang,Eric A. Price,R. Bruce Register,Xiao-Ping Shi,Dorit B. Donoviel,Alan Bernstein,Daria J. Hazuda,Stephen J. Gardell,Yueming Li +13 more
TL;DR: The distinct yet overlapping enzymatic properties of the PS1 γ-secretase complex and the PS2 γ/substantially higher specific activity imply that these two putative aspartyl class proteases may contribute to different biological processes.
Journal ArticleDOI
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
TL;DR: Genetic evidence indicating that the metalloprotease-disintegrin kuzbanian is a new component of the Notch signalling pathway and is involved in Notch activation is presented and differences in the phenotypes of loss-of-function Notch and kuzBanian mutations suggest the existence of alternative Kuzbania-independent mechanisms that generate Notch functional receptors.
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more