The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Journal ArticleDOI
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
Luca Tiberi,Jelle van den Ameele,Jelle van den Ameele,Jordane Dimidschstein,Julie Piccirilli,David Gall,Adèle Herpoel,Angéline Bilheu,Jérôme Bonnefont,Michelina Iacovino,Michael Kyba,Tristan Bouschet,Pierre Vanderhaeghen +12 more
TL;DR: A role for BCL6 in neurogenesis is suggested and Notch-BCL6-Sirt1 interactions that may affect other aspects of physiology and disease are uncovered.
Journal ArticleDOI
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
Shaobo Jin,Anders P. Mutvei,Indira V. Chivukula,Emma R. Andersson,Daniel Ramsköld,Daniel Ramsköld,Rickard Sandberg,Rickard Sandberg,Kian Leong Lee,Pauliina Kronqvist,Veronika Mamaeva,Päivi Östling,J-P Mpindi,Olli-Pekka Kallioniemi,Isabella Screpanti,Lorenz Poellinger,Lorenz Poellinger,Cecilia Sahlgren,Urban Lendahl +18 more
TL;DR: Roles for p53 and IKKα/IKKβ in non-canonical Notch signaling in breast cancer and in the generation of cell context-dependent diversity in the Notch signalling output are revealed.
Journal ArticleDOI
Notch activation as a driver of osteogenic sarcoma.
Jianning Tao,Ming Ming Jiang,Lichun Jiang,Jason S. Salvo,Jason S. Salvo,Huan-Chang Zeng,Brian Dawson,Terry Bertin,Pulivarthi H. Rao,Rui Chen,Rui Chen,Lawrence A. Donehower,Francis H. Gannon,Brendan Lee,Brendan Lee +14 more
TL;DR: It is shown that Notch activation combined with loss of p53 synergistically accelerates OS development in mice, although p53-driven OS is not Rbpj dependent, which demonstrates a dual dominance of the Notch oncogene and p53 mutation in the development of OS.
Journal ArticleDOI
Notch signaling in developmental and tumor angiogenesis.
Natalie Kofler,Carrie J. Shawber,Thaned Kangsamaksin,Hasina Outtz Reed,Josephine Galatioto,Jan Kitajewski +5 more
TL;DR: An exciting discovery, made by several researchers, shows that blocking Notch function in tumor vasculature provides a means by which to suppress tumor growth.
Journal ArticleDOI
A fast growing spectrum of biological functions of γ-secretase in development and disease.
TL;DR: An updated overview of the current knowledge on the diverse molecular mechanisms and signaling pathways controlled by γ-secretase is presented, with a focus on organ development, homeostasis and dysfunction.
References
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Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es,Marielle E. van Gijn,Orbicia Riccio,Maaike van den Born,Marc Vooijs,Harry Begthel,Miranda Cozijnsen,Sylvie Robine,Doug J. Winton,Freddy Radtke,Hans Clevers +10 more
TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more