The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
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Targeting Notch to overcome radiation resistance
TL;DR: The role of Notch in mediating resistance to radiotherapy, the different strategies to block notch in cancer cells and how treatment scheduling can improve tumor response are summarized.
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LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.
Sung-Uk Lee,Sung-Uk Lee,Manami Maeda,Manami Maeda,Yuichi Ishikawa,Yuichi Ishikawa,Sierra Min Li,Anne Wilson,Adrian M. Jubb,Nagisa Sakurai,Lihong Weng,Emma Fiorini,Freddy Radtke,Minhong Yan,H. Robson MacDonald,Ching-Cheng Chen,Takahiro Maeda,Takahiro Maeda +17 more
TL;DR: It is shown that leukemia/lymphoma related factor (LRF) is necessary for HSC maintenance by functioning as an erythroid-specific repressor of Delta-like 4 (Dll4) expression.
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Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer.
Nitin Roper,Moises J. Velez,Alberto Chiappori,Yoo Sun Kim,Jun Wei,Sivasish Sindiri,Nobuyuki Takahashi,Deborah Mulford,Suresh Kumar,Kris Ylaya,Christopher Trindade,Irena Manukyan,Anna-Leigh Brown,Jane B. Trepel,Jung-Min Lee,Stephen M. Hewitt,Javed Khan,Anish Thomas +17 more
TL;DR: In this article, the authors identify predictors of clinical benefit to immunogenomic profiling of tumor samples from patients with relapsed small cell lung cancer (SCLC) and demonstrate a mechanistic link between Notch activation, low NE differentiation and increased intrinsic tumor immunity.
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Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms.
Ashutosh Gupta,Amit Kumar Singh,Ramesh Kumar,Risha Ganguly,Harvesh Kumar Rana,Prabhash K. Pandey,Gautam Sethi,Anupam Bishayee,Abhay K. Pandey +8 more
TL;DR: The aim of this review is to summarize the anticancer efficacy of corilagin with an emphasis on the molecular mechanisms involving various signaling pathways in tumor cells.
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Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.
Dehui Xu,Jinsong Hu,Jinsong Hu,Elke De Bruyne,Eline Menu,Rik Schots,Karin Vanderkerken,Els Van Valckenborgh +7 more
TL;DR: It is demonstrated that Dll1 can activate Notch signaling mostly through Notch2 receptor and can contribute to drug resistance to bortezomib, both in murine and human MM cells, and DAPT (gamma secretase inhibitor) could reverse this effect and increased sensitivity to bortsomib.
References
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Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
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Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
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An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es,Marielle E. van Gijn,Orbicia Riccio,Maaike van den Born,Marc Vooijs,Harry Begthel,Miranda Cozijnsen,Sylvie Robine,Doug J. Winton,Freddy Radtke,Hans Clevers +10 more
TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more