The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TLDR
This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.About:
This article is published in Cell.The article was published on 2009-04-17 and is currently open access. It has received 3120 citations till now. The article focuses on the topics: Notch signaling pathway & Notch 1.read more
Citations
More filters
Journal ArticleDOI
Early signaling events that underlie fate decisions of naive CD4 + T cells toward distinct T-helper cell subsets
Hidehiro Yamane,William E. Paul +1 more
TL;DR: How TCR‐mediated signals in collaboration with the cytokine environment influence the fate decisions of naive CD4+ T cells toward distinct Th subsets at the early stages of activation is reviewed.
Journal ArticleDOI
Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate
Koos E. Hovinga,Fumiko Shimizu,Rong Wang,Georgia Panagiotakos,Maartje Van Der Heijden,Hamideh Moayedpardazi,Ana Sofia Correia,Ana Sofia Correia,Denis Soulet,Tamara Major,Jayanthi Menon,Viviane Tabar +11 more
TL;DR: A novel three‐dimensional organotypic “explant” system of surgical GBM specimens that preserves cytoarchitecture and tumor stroma along with tumor cells is used and suggests a critical role for tumor endothelial cells in GBM stem cell maintenance, mediated at least in part by Notch signaling.
Journal ArticleDOI
Notch as a tumour suppressor.
Craig S. Nowell,Freddy Radtke +1 more
TL;DR: This Review focuses on the latest developments relating specifically to the tumour-suppressor activity of Notch signalling and discusses the potential mechanisms by which Notch can inhibit carcinogenesis in various tissues.
Journal Article
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
Hisamune Kato,Yoshihito Taniguchi,Hisanori Kurooka,Shigeru Minoguchi,Kumiko Tamura,Tasuku Honjo +5 more
TL;DR: In this paper, the authors have compared the activities of mouse RAMIC and its derivatives in transactivation and differentiation suppression of myogenic precursor cells, and they have shown that differentiation suppression by Notch signalling is due to transactivation of genes carrying RBP-J binding motifs.
Journal ArticleDOI
A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development
TL;DR: Interestingly and independent of proliferation, ciliary mutants displayed defects in Notch signaling and commitment of progenitors to differentiate, and Shh signaling defects occurred later, arresting hair follicle morphogenesis in the skin.
References
More filters
Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es,Marielle E. van Gijn,Orbicia Riccio,Maaike van den Born,Marc Vooijs,Harry Begthel,Miranda Cozijnsen,Sylvie Robine,Doug J. Winton,Freddy Radtke,Hans Clevers +10 more
TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.
Related Papers (5)
Notch Signaling: Cell Fate Control and Signal Integration in Development
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more