The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors.
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TLDR
The various aspects of energy homeostasis to which MCH has been associated to are discussed, focusing on the different inputs that feed the MCH peptidergic system with information regarding the homeostatic status of the organism and the exogenous sensory information that drives this system, as well as the outputs that allow MCH to act over a wide range of homeostatics and behavioral controls.Abstract:
The melanin-concentrating hormone [MCH] is an important peptide implicated in the control of motivated behaviors History, however, made this peptide first known for its participation in the control of skin pigmentation, from which its name derives In addition to this peripheral role, MCH is strongly implicated in motivated behaviors, such as feeding, drinking, mating and, more recently, maternal behavior It is suggested that MCH acts as an integrative peptide, converging sensory information and contributing to a general arousal of the organism In this review, we will discuss the various aspects of energy homeostasis to which MCH has been associated to, focusing on the different inputs that feed the MCH peptidergic system with information regarding the homeostatic status of the organism and the exogenous sensory information that drives this system, as well as the outputs that allow MCH to act over a wide range of homeostatic and behavioral controls, highlighting the available morphological and hodological aspects that underlie these integrative actions Besides the well-described role of MCH in feeding behavior, a prime example of hypothalamic-mediated integration, we will also examine those functions in which the participation of MCH has not yet been extensively characterized, including sexual, maternal and defensive behaviors We also evaluated the available data on the distribution of MCH and its function in the context of animals in their natural environment Finally, we briefly comment on the evidence for MCH acting as a coordinator between different modalities of motivated behaviors, highlighting the most pressing open questions that are open for investigations and could provide us with important insights about hypothalamic-dependent homeostatic integrationread more
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A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Daqing Qu,David S. Ludwig,Steen Gammeltoft,Megan Piper,Mary Ann Pelleymounter,Mary Jane Cullen,Wendy Foulds Mathes,Jeanne Przypek,Robin B. Kanarek,Eleftheria Maratos-Flier +9 more
TL;DR: This article showed that one mRNA that is overexpressed in the hypothalamus of ob/ob mice encodes the neuropeptide melanin-concentrating hormone (MCH).
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