Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective.
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In this article, the authors discuss the metabolic crosstalk between tumor cells and cancer-associated Fibroblasts (CAF) and describe the new metabolic pathways newly uncovered in tumor cells.Abstract:
During the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported. Indeed, metabolic reprograming in cancer is much more heterogeneous than initially thought. In particular, a high diversity of carbon sources used by tumor cells has now been shown to contribute to this metabolic heterogeneity in cancer. Moreover, the molecular mechanisms newly highlighted are multiple and shed light on novel actors. Furthermore, the impact of this metabolic heterogeneity on tumor microenvironment has also been an intense subject of research recently. Here, we will describe the new metabolic pathways newly uncovered in tumor cells. We will also have a particular focus on Cancer-Associated Fibroblasts (CAF), whose identity, function and metabolism have been recently under profound investigation. In that sense, we will discuss about the metabolic crosstalk between tumor cells and CAF.read more
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The Role of Cancer-Associated Fibroblasts in Tumor Progression
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TL;DR: A review of the literature comprehensively profiles the roles of cancer-associated fibroblasts (CAFs) implicated in gastrointestinal, endocrine, head and neck, skin, genitourinary, lung, and breast cancers as discussed by the authors.
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Role of cancer-associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer.
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Cancer associated-fibroblast-derived exosomes in cancer progression.
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Mitochondrial Metabolism in Carcinogenesis and Cancer Therapy.
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TL;DR: In this paper, the authors discuss how mitochondria contribute to the initiation of carcinogenesis through gene mutations and production of oncometabolites, and how they promote tumor progression through the control of metabolic reprogramming and mitochondrial dynamics.
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New Immunometabolic Strategy Based on Cell Type-Specific Metabolic Reprogramming in the Tumor Immune Microenvironment
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