Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network
Eric A. Collisson,Joshua D. Campbell,Angela N. Brooks,Angela N. Brooks,Alice H. Berger,William Lee,Juliann Chmielecki,David G. Beer,Leslie Cope,Chad J. Creighton,Ludmila Danilova,Li Ding,Gad Getz,Gad Getz,Peter S. Hammerman,D. Neil Hayes,Bryan Hernandez,James G. Herman,John V. Heymach,Igor Jurisica,Raju Kucherlapati,David J. Kwiatkowski,Marc Ladanyi,Gordon Robertson,Nikolaus Schultz,Ronglai Shen,Rileen Sinha,Carrie Sougnez,Ming-Sound Tsao,William D. Travis,John N. Weinstein,Dennis A. Wigle,Matthew D. Wilkerson,Andy Chu,Andrew D. Cherniack,Angela Hadjipanayis,Mara Rosenberg,Daniel J. Weisenberger,Peter W. Laird,Amie Radenbaugh,Singer Ma,Joshua M. Stuart,Lauren Averett Byers,Stephen B. Baylin,Ramaswamy Govindan,Matthew Meyerson,Matthew Meyerson,Stacey Gabriel,Kristian Cibulskis,Jaegil Kim,Chip Stewart,Lee Lichtenstein,Eric S. Lander,Eric S. Lander,Michael S. Lawrence,E. Getz,E. Getz,Robert S. Fulton,Lucinda Fulton,Michael D. McLellan,Richard K. Wilson,Kai Ye,Catrina Fronick,Christopher G. Maher,Christopher A. Miller,Michael C. Wendl,Christopher R. Cabanski,Elaine R. Mardis,David A. Wheeler,Miruna Balasundaram,Yaron S.N. Butterfield,Rebecca Carlsen,Eric Chuah,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Darlene Lee,Haiyan I. Li,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Richard Varhol,A. Gordon Robertson,Natasja Wye,Nina Thiessen,Robert A. Holt,Steven J.M. Jones,Marco A. Marra,Marcin Imielinski,Marcin Imielinski,Robert C. Onofrio,Eran Hodis,Travis I. Zack,Elena Helman,Chandra Sekhar Pedamallu,Jill P. Mesirov,Gordon Saksena,Steven E. Schumacher,Scott L. Carter,Levi A. Garraway,Levi A. Garraway,Rameen Beroukhim,Rameen Beroukhim,Semin Lee,Harshad S. Mahadeshwar,Angeliki Pantazi,Angeliki Pantazi,Alexei Protopopov,Xiaojia Ren,Sahil Seth,Xingzhi Song,Jiabin Tang,Lixing Yang,Jianhua Zhang,Peng Chieh Chen,Michael Parfenov,Andrew Wei Xu,Netty Santoso,Lynda Chin,Peter J. Park,Katherine A. Hoadley,J. Todd Auman,Shaowu Meng,Yan Shi,Elizabeth Buda,Scot Waring,Umadevi Veluvolu,Donghui Tan,Piotr A. Mieczkowski,Corbin D. Jones,Janae V. Simons,Matthew G. Soloway,Tom Bodenheimer,Stuart R. Jefferys,Jeffrey Roach,Alan P. Hoyle,Junyuan Wu,Saianand Balu,Darshan Singh,Jan F. Prins,James Stephen Marron,Joel S. Parker,Charles M. Perou,Jinze Liu,Dennis T. Maglinte,Philip H. Lai,Moiz S. Bootwalla,David Van Den Berg,Timothy J. Triche,Juok Cho,Daniel DiCara,David I. Heiman,Pei Lin,William Mallard,Douglas Voet,Hailei Zhang,Lihua Zou,Michael S. Noble,Nils Gehlenborg,Helga Thorvaldsdottir,Marc Danie Nazaire,James T. Robinson,B. Arman Aksoy,Giovanni Ciriello,Barry S. Taylor,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Venkatraman E. Seshan,Boris Reva,S. Onur Sumer,Nils Weinhold,Chris Sander,Sam Ng,Jingchun Zhu,Christopher C. Benz,Christina Yau,David Haussler,Paul T. Spellman,Patrick K. Kimes,Bradley M. Broom,Jing Wang,Yiling Lu,Patrick Kwok Shing Ng,Lixia Diao,Wenbin Liu,Christopher I. Amos,Rehan Akbani,Gordon B. Mills,Erin Curley,Joseph Paulauskis,Kevin Lau,Scott Morris,Troy Shelton,David Mallery,Johanna Gardner,Robert Penny,Charles Saller,Katherine Tarvin,William G. Richards,Robert J. Cerfolio,Ayesha S. Bryant,Daniel P. Raymond,Nathan A. Pennell,Carol Farver,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Jennifer Brown,Thomas L. Bauer,Cureline Oleg Dolzhanskiy,Olga Potapova,D L Rotin,Olga Voronina,Elena Nemirovich-Danchenko,Konstantin V. Fedosenko,Anthony A. Gal,Madhusmita Behera,Suresh S. Ramalingam,Gabriel Sica,Douglas B. Flieder,Jeff Boyd,Jo Ellen Weaver,Bernard Kohl,Dang Huy Quoc Thinh,George E. Sandusky,Hartmut Juhl,Edwina Duhig,Peter B. Illei,Edward Gabrielson,James Shin,Beverly Lee,Kristen Rogers,Dante Trusty,Malcolm V. Brock,Christina Williamson,Eric J. Burks,Kimberly M. Rieger-Christ,Antonia H. Holway,Travis Sullivan,Michael K. Asiedu,Farhad Kosari,Natasha Rekhtman,Maureen F. Zakowski,Valerie W. Rusch,Paul Zippile,James Suh,Harvey I. Pass,Chandra Goparaju,Yvonne Owusu-Sarpong,John M. S. Bartlett,Sugy Kodeeswaran,Jeremy Parfitt,Harmanjatinder S. Sekhon,Monique Albert,John Eckman,Jerome Myers,Carl Morrison,Carmelo Gaudioso,Jeffrey A. Borgia,Philip Bonomi,Mark Pool,Michael J. Liptay,Fedor Moiseenko,Irina Zaytseva,Hendrik Dienemann,Michael Meister,Philipp A. Schnabel,Thomas Muley,Martin Peifer,Carmen Gomez-Fernandez,Lynn M. Herbert,Sophie C. Egea,Mei Huang,Leigh B. Thorne,Lori Boice,Ashley H. Salazar,William K. Funkhouser,W. Kimryn Rathmell,Rajiv Dhir,Samuel A. Yousem,Sanja Dacic,Frank Schneider,Jill M. Siegfried,Richard A. Hajek,Mark A. Watson,Sandra McDonald,Bryan F. Meyers,Belinda E. Clarke,Ian A. Yang,Kwun M. Fong,Lindy Hunter,Morgan Windsor,Rayleen V. Bowman,Solange Peters,Igor Letovanec,Khurram Z. Khan,Mark A. Jensen,Eric E. Snyder,Deepak Srinivasan,Ari B. Kahn,Julien Baboud,David Pot,Kenna R. Mills Shaw,Margi Sheth,Tanja Davidsen,John A. Demchok,Liming Yang,Zhining Wang,Roy Tarnuzzer,Jean C. Zenklusen,Bradley A. Ozenberger,Heidi J. Sofia,Richard T. Cheney +318 more
TLDR
In this paper, the authors report molecular profiling of 230 resected lung adnocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses.Abstract:
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.read more
Citations
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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
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Complex heatmaps reveal patterns and correlations in multidimensional genomic data
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TL;DR: UALCAN, an easy to use, interactive web-portal to perform to in-depth analyses of TCGA gene expression data, serves as a platform for in silico validation of target genes and for identifying tumor sub-group specific candidate biomarkers.
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The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification
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TL;DR: The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification.
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Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
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