White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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Autism Pathogenesis: The Superior Colliculus
TL;DR: It is postulates that the superior colliculus is the key structure for such changes for several reasons: it dominates visual behavior during the first months of life, it is ready at birth for complex visual tasks, and it has a significant influence on several hemispheric regions.
Journal ArticleDOI
BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.
Tariq Zaman,Cleusa V.R. de Oliveira,Mahabba Smoka,Chakravarthi Narla,Michael O. Poulter,Susanne Schmid +5 more
TL;DR: It is shown that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, using patch-clamp recordings and voltage-sensitive dye imaging in slices and positive modulation of BK channels in vivo can enhance short-term habituation.
Journal ArticleDOI
Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders
TL;DR: The Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework as mentioned in this paper is designed to reframe the field of prospective studies of neurodevelopmental disorders.
Journal ArticleDOI
Deviation from normative brain development is associated with symptom severity in autism spectrum disorder.
Birkan Tunç,Lisa Yankowitz,Lisa Yankowitz,Drew Parker,Jacob A. Alappatt,Juhi Pandey,Juhi Pandey,Robert T. Schultz,Robert T. Schultz,Ragini Verma +9 more
TL;DR: The approach enables characterization of each individual with reference to normative brain development and identification of distinct developmental subtypes, facilitating a better understanding of developmental heterogeneity in ASD.
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Reduced visual disengagement but intact phasic alerting in young children with autism.
TL;DR: The view that atypical visual disengagement in ASD is related to other factors than atypICALities in the alerting network is supported.
References
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