White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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The Autism Parent Screen for Infants: Predicting risk of autism spectrum disorder based on parent-reported behavior observed at 6–24 months of age:
Lori-Ann R. Sacrey,Lori-Ann R. Sacrey,Susan E. Bryson,Lonnie Zwaigenbaum,Lonnie Zwaigenbaum,Jessica Brian,Isabel M. Smith,Wendy Roberts,Wendy Roberts,Peter Szatmari,Peter Szatmari,Peter Szatmari,Tracy Vaillancourt,Caroline Roncadin,Caroline Roncadin,Nancy Garon +15 more
TL;DR: The sensitivity, specificity, and positive and negative predictive validity of the Autism Parent Screen for Infants highlight its potential for the early screening of autism spectrum disorder in high-risk cohorts.
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Globally weaker and topologically different: resting-state connectivity in youth with autism.
Benjamin E. Yerys,Benjamin E. Yerys,John D. Herrington,John D. Herrington,Theodore D. Satterthwaite,Lisa Guy,Lisa Guy,Robert T. Schultz,Robert T. Schultz,Danielle S. Bassett +9 more
TL;DR: This study clarifies the mixed results reported previously and demonstrates that the functional connectivity metric influences the observed direction of functional connectivity differences for individuals with ASD.
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Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance
TL;DR: The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation, and potential diagnostic markers are discussed as indicators of different processing of social information in ASD.
Journal ArticleDOI
Is mere exposure enough? The effects of bilingual environments on infant cognitive development
TL;DR: It is proposed that exposure to more varied, less predictable (language) environments drive infants to sample more by placing less weight on consolidating familiar information in order to orient sooner to (and explore) new stimuli.
Journal Article
Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge.
TL;DR: Recent advances in developmental social neuroscience promise the advent of cost-effective and community-viable, performance-based procedures, and suggest a complementary method for promoting universal screening and much greater access to the diagnosis process.
References
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Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
TL;DR: The revised interview has been reorganized, shortened, modified to be appropriate for children with mental ages from about 18 months into adulthood and linked to ICD-10 and DSM-IV criteria.
Journal ArticleDOI
Neural Mechanisms of Selective Visual Attention
Robert Desimone,John S. Duncan +1 more
TL;DR: The two basic phenomena that define the problem of visual attention can be illustrated in a simple example and selectivity-the ability to filter out un wanted information is illustrated.
Journal ArticleDOI
The Attention System of the Human Brain
TL;DR: Illustration de trois fonctions principales qui sont predominantes dans l'etude de l'intervention de l'sattention dans les processus cognitifs: 1) orientation vers des evenements sensoriels; 2) detection des signaux par processus focal; 3) maintenir la vigilance en etat d'alerte
Journal ArticleDOI
The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.
Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
TL;DR: Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.
Journal ArticleDOI
Nonrigid registration using free-form deformations: application to breast MR images
TL;DR: The results clearly indicate that the proposed nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms.
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