White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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Early brain development in infants at high risk for autism spectrum disorder
Heather C. Hazlett,Hongbin Gu,Brent C. Munsell,Sun Hyung Kim,Martin Styner,Jason J. Wolff,Jed T. Elison,Meghan R. Swanson,Hongtu Zhu,Kelly N. Botteron,D. Louis Collins,John N. Constantino,Stephen R. Dager,Annette Estes,Alan C. Evans,Vladimir S. Fonov,Guido Gerig,Penelope Kostopoulos,Robert C. McKinstry,Juhi Pandey,Sarah Paterson,John R. Pruett,Robert T. Schultz,Dennis W. W. Shaw,Lonnie Zwaigenbaum,Joseph Piven +25 more
TL;DR: It is shown that hyperexpansion of the cortical surface area between 6 and 12 months of age precedes brain volume overgrowth observed between 12 and 24 months in 15 high-risk infants who were diagnosed with autism at 24 months.
Journal ArticleDOI
The Changing Epidemiology of Autism Spectrum Disorders
Kristen Lyall,Lisa A. Croen,Julie L. Daniels,M. Daniele Fallin,Christine Ladd-Acosta,Brian K. Lee,Brian K. Lee,Bo Y. Park,Nathaniel W. Snyder,Diana Schendel,Diana Schendel,Heather E. Volk,Gayle C. Windham,Craig J. Newschaffer +13 more
TL;DR: Eviologic investigations focused on nongenetic factors have established advanced parental age and preterm birth as ASD risk factors, indicated that prenatal exposure to air pollution and short interpregnancy interval are potentialrisk factors, and suggested the need for further exploration of certain prenatal nutrients, metabolic conditions, and exposure to endocrine-disrupting chemicals.
Journal ArticleDOI
The Cerebellum, Sensitive Periods, and Autism
TL;DR: Evidence that the cerebellum may guide the maturation of remote nonmotor neural circuitry and influence cognitive development and it is proposed that sensitive-period disruption of such internal brain communication can account for autism's key features is reviewed.
Journal ArticleDOI
Precise minds in uncertain worlds: Predictive coding in autism.
Sander Van de Cruys,Kris Evers,Ruth Van der Hallen,Lien Van Eylen,Bart Boets,Lee de-Wit,Johan Wagemans +6 more
TL;DR: It is argued that deficits in executive functioning, theory of mind, and central coherence can all be understood as the consequence of a core deficit in the flexibility with which people with autism spectrum disorder can process violations to their expectations.
Journal ArticleDOI
Developmental pathways to autism: a review of prospective studies of infants at risk.
TL;DR: Prospective studies of infants at familial risk are characterizing developmental pathways to ASD and early neurocognitive markers include atypical neural response to gaze and slowed disengagement.
References
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