White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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Journal ArticleDOI
Unimpaired attentional disengagement in toddlers with autism spectrum disorder.
Jason Fischer,Hayley Smith,Frances Martinez-Pedraza,Alice S. Carter,Nancy Kanwisher,Zsuzsa Kaldy +5 more
TL;DR: This paper found that even at a young age when the clinical symptoms of ASD are first emerging, disengagement abilities are intact, even if the attentional deficit itself is remediated or compensated by the time children with ASD reach school age.
Unimpaired attentional disengagement in toddlers with autism spectrum disorder
Hayley Smith,Frances Martinez-Pedraza,Alice S. Carter,Zsuzsa Kaldy,Jason Fischer,Nancy Kanwisher +5 more
TL;DR: Characterizing attentional disengagement in a group of toddlers just diagnosed with ASD found strikingly similar performance between the ASD and age-matched typically developing (TD) toddlers, and no evidence of impaired attentional disconnection is found.
Journal ArticleDOI
The Importance of Temperament for Understanding Early Manifestations of Autism Spectrum Disorder in High-Risk Infants.
Sarah Paterson,Jason J. Wolff,Jed T. Elison,Breanna Winder-Patel,Lonnie Zwaigenbaum,Annette Estes,Juhi Pandey,Juhi Pandey,Robert T. Schultz,Robert T. Schultz,Kelly N. Botteron,Stephen R. Dager,Heather C. Hazlett,Joseph Piven +13 more
TL;DR: Group differences remained, when early signs of ASD were controlled for, suggesting that temperament differences could be useful targets for understanding the development of ASD.
Journal ArticleDOI
Atypical integration of social cues for orienting to gaze direction in adults with autism
TL;DR: Atypical integration of social cues in ASC for orienting of attention is revealed, suggested to reflect abnormalities in cognitive and neural mechanisms specialized for processing ofSocial cues for attention orienting in ASC.
Journal ArticleDOI
The Neurodevelopment of Autism from Infancy Through Toddlerhood.
Jessica B. Girault,Joseph Piven +1 more
TL;DR: Neuroimaging studies of brain development in ASD from birth through toddlerhood are reviewed, relate these findings to candidate neurobiological mechanisms, and discuss implications for future research and translation to clinical practice.
References
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Neural Mechanisms of Selective Visual Attention
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TL;DR: Illustration de trois fonctions principales qui sont predominantes dans l'etude de l'intervention de l'sattention dans les processus cognitifs: 1) orientation vers des evenements sensoriels; 2) detection des signaux par processus focal; 3) maintenir la vigilance en etat d'alerte
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The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.
Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
TL;DR: Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.
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