White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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Executive function in the first three years of life: precursors, predictors and patterns
TL;DR: This article identified four domains critical to the development of executive function: control of attention, self-regulation, processing speed and cognitive flexibility, and identified individual differences within these domains have clinical significance both in terms of the identification of risk markers for later executive dysfunction and for the target or delivery of early intervention to ameliorate this risk.
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Longitudinal patterns of repetitive behavior in toddlers with autism.
Jason J. Wolff,Kelly N. Botteron,Stephen R. Dager,Jed T. Elison,Annette Estes,Hongbin Gu,Heather C. Hazlett,Juhi Pandey,Sarah Paterson,Robert T. Schultz,Lonnie Zwaigenbaum,Joseph Piven +11 more
TL;DR: Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12-month time point, and a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD.
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Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.
TL;DR: Robust evidence of disrupted sensory processing in individuals with ASD and FXS is outlined, and in respective animal models, focusing on the auditory sensory domain.
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Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem
TL;DR: Deficits precisely and consistently directing eye movements suggest impairment in the error-reducing function of the cerebellum in ASD.
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Toward a conceptual framework for early brain and behavior development in autism.
TL;DR: A conceptual framework for the early, post-natal development of autism is suggested, postulates that an increase in the proliferation of neural progenitor cells and hyper-expansion of cortical surface area in the first year, occurring during a pre-symptomatic period characterized by disrupted sensorimotor and attentional experience, leads to altered experience-dependent neuronal development and decreased elimination of neuronal processes.
References
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Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
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