White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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Journal ArticleDOI
On the emergence of autism: neuroimaging findings from birth to preschool
Jason J. Wolff,Joseph Piven +1 more
TL;DR: For example, this paper found evidence of increased cortical gray and white matter volumes, increased amygdala volumes, aberrant structural and functional connectivity, and atypical neurodevelopmental trajectories.
Proceedings ArticleDOI
A statistical framework for the classification of infant DT images
Mahmoud Mostapha,Ahmed Soliman,Fahmi Khalifa,Ahmed Elnakib,Amir Alansary,Matthew Nitzken,Manuel F. Casanova,Ayman El-Baz +7 more
TL;DR: A new adaptive atlas-based framework for the automated segmentation of different brain structures from infant diffusion tensor images (DTI) is introduced, constructed from a prior atlas database built using a subset of co-aligned training data sets that is adapted during the segmentation process guided by the visual appearance characteristics of several DTI features.
Journal ArticleDOI
Heart rate-defined sustained attention in infants at risk for autism.
TL;DR: Heart rate-defined sustained attention served as a global biological measure of attention in high-risk infants, predicting greater variability in group risk status than behavioral looking alone and suggesting abnormal qualities of HRDSA may inform individual differences within this population.
References
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Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
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Nonrigid registration using free-form deformations: application to breast MR images
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