White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
More filters
Journal ArticleDOI
Visual social attention in autism spectrum disorder: Insights from eye tracking studies.
TL;DR: Results show that social orienting is actually not qualitatively impaired and that decreased attention to faces does not generalized across contexts.
Journal ArticleDOI
Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age
Robert W. Emerson,Chloe M. Adams,Tomoyuki Nishino,Heather C. Hazlett,Jason J. Wolff,Lonnie Zwaigenbaum,John N. Constantino,Mark D. Shen,Meghan R. Swanson,Jed T. Elison,Sridhar Kandala,Annette Estes,Kelly N. Botteron,Louis Collins,Stephen R. Dager,Alan C. Evans,Guido Gerig,Hongbin Gu,Robert C. McKinstry,Sarah Paterson,Robert T. Schultz,Martin Styner,Bradley L. Schlaggar,John R. Pruett,Joseph Piven +24 more
TL;DR: Prospective neuroimaging of 59 6-month-old infants with a high familial risk for ASD correctly identified which individual children would receive a research clinical best-estimate diagnosis of ASD at 24 months of age, which has clinical implications for early risk assessment and the feasibility of developing early preventative interventions for ASD.
Journal ArticleDOI
Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life
Annette Estes,Lonnie Zwaigenbaum,Hongbin Gu,Tanya St John,Sarah Paterson,Jed T. Elison,Heather C. Hazlett,Kelly N. Botteron,Stephen R. Dager,Robert T. Schultz,Penelope Kostopoulos,Alan C. Evans,Geraldine Dawson,Geraldine Dawson,Jordana Eliason,Shanna L. Alvarez,Joseph Piven +16 more
TL;DR: Findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants.
Journal ArticleDOI
Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder.
TL;DR: Evidence for impaired white matter connectivity as a neural substrate for socio-emotional dysfunction in ASD is reviewed and future efforts to further elucidate the nature of atypical white matter development may offer new insights into etiological mechanisms contributing to ASD impairments and uncover novel opportunities for targeted intervention.
Journal ArticleDOI
Eye tracking in early autism research
TL;DR: It is concluded that eye tracking can reveal important features of the complex picture of autism.
References
More filters
Journal ArticleDOI
Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
TL;DR: The revised interview has been reorganized, shortened, modified to be appropriate for children with mental ages from about 18 months into adulthood and linked to ICD-10 and DSM-IV criteria.
Journal ArticleDOI
Neural Mechanisms of Selective Visual Attention
Robert Desimone,John S. Duncan +1 more
TL;DR: The two basic phenomena that define the problem of visual attention can be illustrated in a simple example and selectivity-the ability to filter out un wanted information is illustrated.
Journal ArticleDOI
The Attention System of the Human Brain
TL;DR: Illustration de trois fonctions principales qui sont predominantes dans l'etude de l'intervention de l'sattention dans les processus cognitifs: 1) orientation vers des evenements sensoriels; 2) detection des signaux par processus focal; 3) maintenir la vigilance en etat d'alerte
Journal ArticleDOI
The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.
Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
TL;DR: Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.
Journal ArticleDOI
Nonrigid registration using free-form deformations: application to breast MR images
TL;DR: The results clearly indicate that the proposed nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms.
Related Papers (5)
Differences in white matter fiber tract development present from 6 to 24 months in infants with autism.
Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism
Warren Jones,Ami Klin +1 more