White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Jed T. Elison,Sarah Paterson,Jason J. Wolff,J. Steven Reznick,Noah J. Sasson,Hongbin Gu,Kelly N. Botteron,Stephen R. Dager,Annette Estes,Alan C. Evans,Guido Gerig,Heather C. Hazlett,Robert T. Schultz,Martin Styner,Lonnie Zwaigenbaum,Joseph Piven +15 more
TLDR
Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.Abstract:
Specific differences in visual orienting, critical in social-cognitive development, are associated with differences in white matter microstructure of the splenium.read more
Citations
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The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders
Matthew W. Mosconi,Matthew W. Mosconi,Zheng Wang,Lauren M. Schmitt,Peter T. Tsai,John A. Sweeney +5 more
TL;DR: It is proposed that cerebellar circuits may prove to be promising targets for therapeutic development aimed at rescuing sensorimotor and other clinical symptoms of different forms of ASD.
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Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey.
Marwa Ismail,Robert S. Keynton,Mahmoud Mostapha,Ahmed ElTanboly,Manuel F. Casanova,Georgy Gimel'farb,Ayman El-Baz +6 more
TL;DR: This survey demonstrates the absence of consistent pathology in the brains of autistic children and lack of research investigations in patients under 2 years of age in the literature.
Journal ArticleDOI
Prospective examination of visual attention during play in infants at high-risk for autism spectrum disorder: A longitudinal study from 6 to 36 months of age
TL;DR: This prospective longitudinal study is the first to describe the development of components of visual attention, including engaging, sustaining, and disengaging attention, in infants at high-risk of developing ASD (each with an older sibling with ASD).
Journal ArticleDOI
Developmental change in look durations predicts later effortful control in toddlers at familial risk for ASD
Alexandra Hendry,Emily J.H. Jones,Rachael Bedford,Teodora Gliga,Tony Charman,Mark H. Johnson +5 more
TL;DR: The finding that prolonged attention to faces may be an early indicator of disruption to the executive attention system is of potential value in screening for infants at risk for later EF difficulties and for evaluation of intervention outcomes.
Journal ArticleDOI
Identification of infants at high-risk for autism spectrum disorder using multiparameter multiscale white matter connectivity networks.
TL;DR: The feasibility of using machine learning techniques for identifying high‐risk ASD infants at as early as six months after birth is demonstrated and a novel multikernel support vector machine classification framework is proposed by using the connectivity features gathered from WM connectivity networks.
References
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