Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
Hong Shi,Hua Zhong,Yi Peng,Yongli Dong,Xuebin Qi,Feng Zhang,Lu-Fang Liu,Si-Jie Tan,Runlin Z. Ma,Chunjie Xiao,R. Spencer Wells,Li Jin,Bing Su +12 more
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TLDR
It is proposed that D-M174 has a southern origin and its northward expansion occurred about 60,000 years ago, predating the northward migration of other major East Asian lineages.Abstract:
The phylogeography of the Y chromosome in Asia previously suggested that modern humans of African origin initially settled in mainland southern East Asia, and about 25,000–30,000 years ago, migrated northward, spreading throughout East Asia. However, the fragmented distribution of one East Asian specific Y chromosome lineage (D-M174), which is found at high frequencies only in Tibet, Japan and the Andaman Islands, is inconsistent with this scenario. In this study, we collected more than 5,000 male samples from 73 East Asian populations and reconstructed the phylogeography of the D-M174 lineage. Our results suggest that D-M174 represents an extremely ancient lineage of modern humans in East Asia, and a deep divergence was observed between northern and southern populations. We proposed that D-M174 has a southern origin and its northward expansion occurred about 60,000 years ago, predating the northward migration of other major East Asian lineages. The Neolithic expansion of Han culture and the last glacial maximum are likely the key factors leading to the current relic distribution of D-M174 in East Asia. The Tibetan and Japanese populations are the admixture of two ancient populations represented by two major East Asian specific Y chromosome lineages, the O and D haplogroups.read more
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Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
Cynthia M. Beall,Gianpiero L. Cavalleri,Libin Deng,Robert C. Elston,Gao Yang,Jo Knight,Chaohua Li,Jiang Chuan Li,Yu Liang,Mark McCormack,Hugh Montgomery,Hao Pan,Peter A. Robbins,Kevin V. Shianna,Siu-Cheung Tam,Ngodrop Tsering,Krishna R. Veeramah,Wei Wang,Puchung Wangdui,Michael E. Weale,Yaomin Xu,Zhe Xu,Ling Yang,M Justin Zaman,Changqing Zeng,Li Zhang,Xianglong Zhang,Pingcuo Zhaxi,Yong-Tang Zheng +28 more
TL;DR: Evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants.
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Genetic variations in Tibetan populations and high altitude adaptation at the Himalayas
Yi Peng,Zhaohui Yang,Hui Zhang,Chaoying Cui,Xuebin Qi,Xiong-Jian Luo,Xiang Tao,Tianyi Wu,Ouzhuluobu,Basang,Ciwangsangbu,Danzengduojie,Hua Chen,Hong Shi,Bing Su +14 more
TL;DR: Analysis of genome-wide sequence variations in Tibetans indicates strong signals of selective sweep in two hypoxia-related genes, EPAS1 and EGLN1, and suggests that during the long-term occupation of high-altitude areas, the functional sequence variations for acquiring biological adaptation to high-Altitude Hypoxia have been enriched in Tibetan populations.
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A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans
Shuhua Xu,Shilin Li,Yajun Yang,Jingze Tan,Haiyi Lou,Wenfei Jin,Ling Yang,Xuedong Pan,Jiucun Wang,Yiping Shen,Bai-Lin Wu,Bai-Lin Wu,Hongyan Wang,Li Jin,Li Jin +14 more
TL;DR: In this article, the authors conducted a genome-wide study of 1,000,000 genetic variants in 46 Tibetans and 92 Han Chinese (HAN) for identifying the signals of high-altitude adaptations (HAAs) in Tibetan genomes.
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Modeling recent human evolution in mice by expression of a selected EDAR variant
Yana G. Kamberov,Sijia Wang,Sijia Wang,Jingze Tan,Pascale Gerbault,Abigail R. Wark,Longzhi Tan,Yajun Yang,Shilin Li,Kun Tang,Hua Chen,Adam Powell,Yuval Itan,Dorian Q. Fuller,Jason Lohmueller,Junhao Mao,Asa Schachar,Asa Schachar,Madeline Paymer,Madeline Paymer,Elizabeth Hostetter,Elizabeth H. Byrne,Melissa Burnett,Andrew P. McMahon,Mark G. Thomas,Daniel E. Lieberman,Li Jin,Li Jin,Clifford J. Tabin,Bruce A. Morgan,Pardis C. Sabeti,Pardis C. Sabeti +31 more
TL;DR: It is found that EDAR370A is associated with an increased number of active eccrine glands in the Han Chinese, and this interdisciplinary approach yields unique insight into the generation of adaptive variation among modern humans.
Journal ArticleDOI
Mitochondrial Genome Evidence Reveals Successful Late Paleolithic Settlement on the Tibetan Plateau
Mian Zhao,Qing-Peng Kong,Hua-Wei Wang,Min-Sheng Peng,Xiao-Dong Xie,Wen-Zhi Wang,Jiayang,Jian-Guo Duan,Ming-Cui Cai,Shi-Neng Zhao,Cidanpingcuo,Yuan-Quan Tu,Shi-Fang Wu,Yong-Gang Yao,H.-J. Bandelt,Ya-Ping Zhang +15 more
TL;DR: The results confirm that the vast majority of Tibetan matrilineal components can trace their ancestry to Epipaleolithic and Neolithic immigrants from northern China during the mid-Holocene and identify an infrequent novel haplogroup, M16, that branched off directly from the Eurasian M founder type.
References
More filters
Journal ArticleDOI
Sea Level Change Through the Last Glacial Cycle
Kurt Lambeck,John Chappell +1 more
TL;DR: For example, in this paper, the authors show that the earth-response function is depth dependent as well as spatially variable, and that the migration of coastlines can be predicted during glacial cycles, including the anthropologically important period from about 60,000 to 20,000 years ago.
Journal ArticleDOI
Y chromosome sequence variation and the history of human populations
Peter A. Underhill,Peidong Shen,A. A. Lin,Li Jin,Giuseppe Passarino,Wei-Hsien Yang,Kauffman E,Batsheva Bonne-Tamir,Jaume Bertranpetit,Paolo Francalacci,Muntaser E. Ibrahim,Trefor Jenkins,Kidd,S.Q. Mehdi,Mark Seielstad,R. S. Wells,Alberto Piazza,Ronald W. Davis,Marcus W. Feldman,Luigi Luca Cavalli-Sforza,Peter J. Oefner +20 more
TL;DR: Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of the authors' species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history.
Journal ArticleDOI
A nomenclature system for the tree of human Y-chromosomal binary haplogroups
TL;DR: A simple set of rules was developed to unambiguously label the different clades nested within a single most parsimonious phylogeny, which supersedes and unifies past nomenclatures and allows the inclusion of additional mutations and haplogroups yet to be discovered.
Journal ArticleDOI
The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective.
Ornella Semino,Ornella Semino,Giuseppe Passarino,Giuseppe Passarino,Peter J. Oefner,Alice A. Lin,Svetlana Arbuzova,Lars Beckman,Giovanna De Benedictis,Paolo Francalacci,Anastasia Kouvatsi,Svetlana A. Limborska,Mladen Marcikiæ,Anna Mika,Barbara Mika,Dragan Primorac,A. Silvana Santachiara-Benerecetti,Luigi Luca Cavalli-Sforza,Peter A. Underhill +18 more
TL;DR: A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.
Journal ArticleDOI
The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
Peter A. Underhill,Giuseppe Passarino,A. A. Lin,Peidong Shen,Marta Mirazón Lahr,Marta Mirazón Lahr,Robert Foley,Peter J. Oefner,Luigi Luca Cavalli-Sforza +8 more
TL;DR: A set of unique event polymorphisms associated with the non‐recombining portion of the Y‐chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges.