A
Akari Suzuki
Researcher at University of Tokyo
Publications - 6
Citations - 2256
Akari Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Genome-wide association study & Genetic association. The author has an hindex of 5, co-authored 6 publications receiving 1848 citations.
Papers
More filters
Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun,Julio E. Molineros,Loren L. Looger,Xu-jie Zhou,Kwangwoo Kim,Yukinori Okada,Jianyang Ma,Yuan-yuan Qi,Xana Kim-Howard,Prasenjeet Motghare,Krishna Bhattarai,Adam Adler,So Young Bang,Hye Soon Lee,Tae-Hwan Kim,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Yong Beom Park,Jung Yoon Choe,Seung Cheol Shim,Yuta Kochi,Akari Suzuki,Michiaki Kubo,Takayuki Sumida,Kazuhiko Yamamoto,Shin-Seok Lee,Young-Jin Kim,Bok Ghee Han,Mikhail G. Dozmorov,Kenneth M. Kaufman,Jonathan D. Wren,John B. Harley,Nan Shen,Nan Shen,Kek Heng Chua,Hong Zhang,Sang Cheol Bae,Swapan K. Nath +38 more
TL;DR: Ten new SLE susceptibility loci are identified and the new loci share functional and ontological characteristics with previously reported loci and are possible drug targets for SLE therapeutics.
Journal ArticleDOI
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
Katsuhiko Nakashima,Satoko Arai,Akari Suzuki,Yuko Nariai,Takeshi Urano,Manabu Nakayama,Osamu Ohara,Ken Ichi Yamamura,Kazuhiko Yamamoto,Toru Miyazaki +9 more
TL;DR: It is shown that PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc expression and lymphoid enhancer-binding factor 1 and histone deacetylase 1 at the upstream region of the c- myc gene.
Journal ArticleDOI
Genetic basis of rheumatoid arthritis: a current review.
TL;DR: The genetic architecture of RA as determined through GWASs and meta-analyses is described and the potential use of genetic data in clinical practice in RA treatment is examined, which represents a challenge in medical genetics in the post-GWAS era.
Journal ArticleDOI
Genetics of rheumatoid arthritis in Asia—present and future
TL;DR: The genetic heterogeneity observed in the PADI4 and PTPN22 genes suggests that ethnic variation should be considered in patients of Asian populations.